Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele.
作者信息
Kennedy L J, Quarmby S, Happ G M, Barnes A, Ramsey I K, Dixon R M, Catchpole B, Rusbridge C, Graham P A, Hillbertz N S, Roethel C, Dodds W J, Carmichael N G, Ollier W E R
机构信息
Centre for Integrated Genomic Medical Research, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
出版信息
Tissue Antigens. 2006 Jul;68(1):82-6. doi: 10.1111/j.1399-0039.2006.00614.x.
Dogs exhibit a range of immune-mediated conditions including a lymphocytic thyroiditis which has many similarities to Hashimoto's thyroiditis in man. We have recently reported an association in Doberman Pinschers between canine hypothyroidism and a rare DLA class II haplotype that contains the DLA-DQA100101 allele. We now report a further series of 173 hypothyroid dogs in a range of breeds where a significant association with DLA-DQA100101 is shown.
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