Debnath M, Chaudhuri T K
Cellular Immunology Laboratory, Department of Zoology, University of North Bengal, Siliguri, West Bengal, India.
Tissue Antigens. 2006 Jan;67(1):64-5. doi: 10.1111/j.1399-0039.2005.00517.x.
The frequency of HLA-A and HLA-B locus alleles was studied by using polymerase chain reaction-based sequence-specific primer method in a very primitive and vanishing sub-Himalayan Indian Tribe, the Toto population of North Bengal. The Toto, a Mongoloid tribe with a population size of 1172 reside only in the Totopara of Jalpaiguri district of North Bengal. We studied 40 individuals and observed some high frequency alleles when compared to other Indian tribal, non-tribal, and major world populations. Particularly, the frequency of HLA-B14 was 32.5% in the Toto population, the highest known frequency reported in any population in the world. This indigenous tribal population may harbour novel HLA alleles and unique haplotypes which extensive HLA genotyping will help to reveal, and thus further our understanding of their genetic admixture and migration patterns.
采用基于聚合酶链反应的序列特异性引物方法，对印度喜马拉雅山次区域一个非常原始且人口逐渐减少的部落——北孟加拉的托托族进行了HLA - A和HLA - B基因座等位基因频率的研究。托托族是一个蒙古人种部落，人口规模为1172人，仅居住在北孟加拉邦 Jalpaiguri 区的托托帕拉。我们研究了40名个体，与其他印度部落、非部落以及世界主要人群相比，观察到了一些高频等位基因。特别是，托托族人群中HLA - B14的频率为32.5%，这是世界上任何人群中报道的已知最高频率。这个本土部落人群可能蕴藏着新的HLA等位基因和独特的单倍型，广泛的HLA基因分型将有助于揭示这些，从而进一步加深我们对其基因混合和迁移模式的理解。
