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人类迁移、多样性与疾病关联:既定和新兴 DNA 标记的趋同作用。

Human migration, diversity and disease association: a convergent role of established and emerging DNA markers.

机构信息

Cellular Immunology Laboratory, Department of Zoology, University of North Bengal, Siliguri West Bengal, India.

出版信息

Front Genet. 2013 Aug 9;4:155. doi: 10.3389/fgene.2013.00155. eCollection 2013.

Abstract

With the gradual development of intelligence, human got curious to know his origin and evolutionary background. Historical statements and anthropological findings were his primary tool for solving the puzzles of his own origin, until came the golden era of molecular markers which took no time to prove it's excellence in unveiling answers to the questions regarding the migration pattern of human across different geographical regions. As a bonus these markers proved very much beneficial in solving criminal offenses and in understanding the etiology of many dreaded diseases and to design their prevention. In this review, we have aimed to throw light on some of the promising molecular markers which are very much in application now-a-days for not only understanding the evolutionary background and ancient migratory routes of humans but also in the field of forensics and human health.

摘要

随着智能的逐步发展,人类开始好奇地想要了解自己的起源和进化背景。历史记载和人类学发现是他主要的工具,用于解决他自己起源的谜题,直到分子标记的黄金时代到来,它很快证明了在揭示人类在不同地理区域的迁移模式方面的答案的卓越性。作为额外的好处,这些标记物在解决犯罪行为以及理解许多可怕疾病的病因并设计预防措施方面也非常有帮助。在这篇综述中,我们旨在阐明一些有前途的分子标记物,这些标记物现在不仅用于了解人类的进化背景和古代迁徙路线,也用于法医学和人类健康领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05fb/3738866/4aefa916ad15/fgene-04-00155-g001.jpg

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