泰国人群中HLA II类单倍型与格雷夫斯病之间的关联。

The association between HLA class II haplotype with Graves' disease in Thai population.

作者信息

Wongsurawat T, Nakkuntod J, Charoenwongse P, Snabboon T, Sridama V, Hirankarn N

机构信息

Inter-Department of Medical Microbiology, Graduate School, Chulalongkorn University, Bangkok, Thailand.

出版信息

Tissue Antigens. 2006 Jan;67(1):79-83. doi: 10.1111/j.1399-0039.2005.00498.x.

DOI:10.1111/j.1399-0039.2005.00498.x

PMID:16451208

Abstract

The distribution of HLA-DRB1, -DQA1 and -DQB1 alleles were analysed in 124 Graves' disease (GD) patients compared to 124 normal controls in order to identify the alleles/haplotypes associated with GD in Thai population. The DRB11602-DQA10102-DQB10502 haplotype was significantly increased in GD patients (P = 0.0209, OR = 2.55). DRB107-DQA10201-DQB10201 haplotype (P = 0.039, OR = 0.32) and HLA-DRB112-DQA10601-DQB10301 haplotype (P = 0.0025, OR = 0.28) were significantly decreased in GD patients. Interestingly, a protective DRB107 allele in Thai population lacks an arginine at position 74 similar to DRB10311 (a protective allele in Caucasians). A significant association of DRB11602-DQA10102-DQB10502 and HLA-DRB112-DQA10601-DQB10301 alleles and haplotypes with GD was recently reported in Korean but not in any Caucasian studies. Thus, DRB11602 allele and closely linked haplotype, DRB11602-DQA10102-DQB1*0502, might serve as a marker for genetic susceptibility to GD in Asian population.

摘要

为了确定泰国人群中与格雷夫斯病（GD）相关的等位基因/单倍型，对124例GD患者和124例正常对照者的HLA-DRB1、-DQA1和-DQB1等位基因分布进行了分析。GD患者中DRB11602-DQA10102-DQB10502单倍型显著增加（P = 0.0209，OR = 2.55）。DRB107-DQA10201-DQB10201单倍型（P = 0.039，OR = 0.32）和HLA-DRB112-DQA10601-DQB10301单倍型（P = 0.0025，OR = 0.28）在GD患者中显著减少。有趣的是，泰国人群中具有保护作用的DRB107等位基因在第74位缺乏精氨酸，类似于DRB10311（白种人中的一个保护等位基因）。最近在韩国报道了DRB11602-DQA10102-DQB10502和HLA-DRB112-DQA10601-DQB10301等位基因及单倍型与GD有显著关联，但在任何白种人研究中均未报道。因此，DRB11602等位基因及其紧密连锁的单倍型DRB11602-DQA10102-DQB1*0502可能是亚洲人群GD遗传易感性的一个标志物。