人类免疫缺陷病毒感染情况不一致的泰国夫妇中人类白细胞抗原II类（DRB1、DQA1和DQB1）等位基因及单倍型频率

HLA class II (DRB1, DQA1 and DQB1) allele and haplotype frequencies among HIV-infection discordant Thai couples.

作者信息

Bejrachandra Sasitom, Kitayaporn Dwip, Kaewkungwal Jaranit, Piya-Anant Manee, Permpikul Parichart, Sirikong Monchan, Siriboonrit Usanee, Chandanayingyong Dasnayanee

机构信息

Department of Transfusion Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700 Thailand.

出版信息

Asian Pac J Allergy Immunol. 2004 Jun-Sep;22(2-3):143-51.

PMID:15565951

Abstract

We investigated the association of HLA-DRB1, -DQA1 and -DQB1 alleles and haplotypes in 33 Thai HIV discordant couples. A significantly lower frequencies of DRB114 (3.0% vs 11.3%, p = 0.048) and DQA10103 (0.0% vs 5.63%, p = 0.042) alleles were found in the seropositive individuals when compared with HIV-negative controls. In contrast, there was no significant difference in HLA-DQB1* allele frequencies. The haplotype analysis revealed that DRB11501-DQA10102-DQB10601 (7.6% vs 0.0%, p = 0.002), DRB10405-DQA10302-DQB10401 (7.6% vs 1.3%, p = 0.024) and DRB11401-DQA10104-DQB105031 (6.1% vs 0.0%, p = 0.007) were found to be significantly higher frequencies when compared between HIV seronegative partners and HIV negative controls, but DRB11501-DQA10102-DQB10502 (0.0% vs 8.1%, p = 0.01) was significantly lower. The DRB11602-DQA10101-DQB10502 (4.6% vs 0.0%, p = 0.024) haplotype was found to be significantly higher frequencies in HIV seropositive individuals when compared to HIV negative controls but the DRB11502-DQA10101-DQB10501 (1.5% vs 8.1%, p = 0.049) haplotype was lower.

摘要

我们研究了33对泰国HIV血清学不一致夫妇中HLA - DRB1、- DQA1和 - DQB1等位基因及单倍型的关联。与HIV阴性对照相比，在血清阳性个体中发现DRB114（3.0%对11.3%，p = 0.048）和DQA10103（0.0%对5.63%，p = 0.042）等位基因的频率显著降低。相比之下，HLA - DQB1等位基因频率没有显著差异。单倍型分析显示，与HIV血清阴性伴侣和HIV阴性对照相比，DRB11501 - DQA10102 - DQB10601（7.6%对0.0%，p = 0.002）、DRB10405 - DQA10302 - DQB1040（7.6%对1.3%，p = 0.024）和DRB11401 - DQA10104 - DQB105031（6.1%对0.0%，p = 0.007）的频率显著更高，但DRB11501 - DQA10102 - DQB10502（0.0%对8.1%，p = 0.01）显著更低。与HIV阴性对照相比，发现DRB11602 - DQA10101 - DQB10502（4.6%对0.0%，p = 0.024）单倍型在HIV血清阳性个体中的频率显著更高，但DRB11502 - DQA10101 - DQB1*0501（1.5%对8.1%，p = 0.049）单倍型更低。