利用两疾病基因座模型分析酗酒相关基因。
Analysis of genes for alcoholism using two-disease-locus models.
机构信息
Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
出版信息
BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S149. doi: 10.1186/1471-2156-6-S1-S149.
Abstract
Using model-based two-locus methods for mapping genes, we analyzed the family data from the Collaborative Study on the Genetics of Alcoholism. Microsatellite data from 143 families ascertained through having three or more individuals affected with alcohol dependence were used for this investigation. Four regions showing evidence for linkage were identified using single-locus models from previous investigations. We investigated the genetic linkage, pattern of disease inheritance, and pair-wise genetic epistasis of these loci using the TLINKAGE program for two-disease-locus analysis.
摘要
采用基于模型的两基因座定位方法，我们分析了酒精中毒遗传合作研究的家族资料。这项研究使用了通过三个或更多受酒精依赖影响的个体确定的 143 个家族的微卫星资料。以前的研究采用单基因座模型，确定了四个有连锁证据的区域。我们使用 TLINKAGE 程序进行两疾病基因座分析，研究这些基因座的遗传连锁、疾病遗传方式和基因间的两两遗传上位性。
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