INSERM U535, 94817 Villejuif Cedex, Villejuif, France.
BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S18. doi: 10.1186/1471-2156-6-S1-S18.
The objective of this study is to evaluate the efficacy of a model-free linkage statistics for finding evidence of linkage using two different maps and to illustrate how the comparison of results from several populations might provide insight into the underlying genetic etiology of the disease of interest. The results obtained in terms of detection of the risk loci and threshold for declaring linkage and power are very similar for a dense SNP map and a sparser microsatellite map. The populations differed in terms of family ascertainment and diagnosis criteria, leading to different power to detect the individual underlying disease loci. Our results for the individual replicates are consistent with the disease model used in the simulation.
本研究旨在评估一种无模型连锁统计方法在使用两种不同图谱时发现连锁证据的功效，并说明比较多个群体的结果如何为感兴趣疾病的潜在遗传病因学提供深入了解。对于密集 SNP 图谱和稀疏微卫星图谱，在检测风险基因座和宣布连锁的阈值以及功效方面，得到的结果非常相似。群体之间在家族确定和诊断标准方面存在差异，导致检测个体潜在疾病基因座的能力不同。我们对个体重复的结果与模拟中使用的疾病模型一致。
