The Department of Epidemiology, UT MD Anderson Cancer Center, Houston, TX, USA.
BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S43. doi: 10.1186/1471-2156-6-S1-S43.
We present a meta-analysis procedure for genome-wide linkage studies (MAGS). The MAGS procedure combines genome-wide linkage results across studies with possibly distinct marker maps. We applied the MAGS procedure to the simulated data from the Genetic Analysis Workshop 14 in order to investigate power to detect linkage to disease genes and power to detect linkage to disease modifier genes while controlling for type I error. We analyzed all 100 replicates of the four simulated studies for chromosomes 1 (disease gene), 2 (modifier gene), 3 (disease gene), 4 (no disease gene), 5 (disease gene), and 10 (modifier gene) with knowledge of the simulated disease gene locations. We found that the procedure correctly identified the disease loci on chromosomes 1, 3, and 5 and did not erroneously identify a linkage signal on chromosome 4. The MAGS procedure provided little to no evidence of linkage to the disease modifier genes on chromosomes 2 and 10.
我们提出了一种用于全基因组连锁研究（MAGS）的荟萃分析程序。该 MAGS 程序结合了具有可能不同标记图谱的研究中的全基因组连锁结果。我们将 MAGS 程序应用于遗传分析研讨会 14 的模拟数据，以调查在控制 I 型错误的情况下检测疾病基因连锁和检测疾病修饰基因连锁的能力。我们分析了四个模拟研究的所有 100 个重复项，涉及染色体 1（疾病基因）、2（修饰基因）、3（疾病基因）、4（无疾病基因）、5（疾病基因）和 10（修饰基因），同时了解模拟疾病基因的位置。我们发现该程序正确地识别了染色体 1、3 和 5 上的疾病位点，并且没有错误地识别出染色体 4 上的连锁信号。MAGS 程序对染色体 2 和 10 上的疾病修饰基因几乎没有提供连锁证据。
