Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, University at Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S75. doi: 10.1186/1471-2156-6-S1-S75.
Haplotype-based methods have become increasingly popular in the last decade because shared lengths in haplotypes can be used for disease localization. In this contribution, we propose a novel linkage-based haplotype-sharing approach for quantitative traits based on the class of Mantel statistics which is closely related to the weighted pair-wise correlation statistic. Because these statistics are known to be liberal, we propose a permutation test to evaluate significance. We applied the Mantel statistic to the autosomal data from the genome-wide scan of the Collaborative Study on the Genetics of Alcoholism with the Affymetrix Genotype 10 K array that was provided for the Genetic Analysis Workshop 14. Four regions on chromosome 4, 8, 16, and 20 showed p-values less than 0.005 with a minimum p-value of < 0.0001 on chromosome 16 (tsc0520638 at 72.8 cM). Three of these four regions located on chromosome 4, 16, and 20 have been reported previously in the Genetic Analysis Workshop 11.
基于单体型的方法在过去十年中变得越来越流行，因为单体型中的共享长度可用于疾病定位。在本研究中，我们提出了一种基于连锁的新型单体型共享方法，用于基于 Mantel 统计量的数量性状，该统计量与加权成对相关统计量密切相关。由于这些统计量被认为是宽松的，我们提出了一种置换检验来评估其显著性。我们将 Mantel 统计量应用于合作酒精中毒遗传学基因组扫描的常染色体数据，该数据由 Affymetrix Genotype 10 K 阵列提供，用于 14 届遗传分析研讨会。在染色体 4、8、16 和 20 上有四个区域的 p 值小于 0.005，在染色体 16 上的最小 p 值小于 0.0001（72.8 cM 处的 tsc0520638）。这四个区域中的三个位于染色体 4、16 和 20 上，之前在 11 届遗传分析研讨会上有报道过。
