te Meerman G J, Van der Meulen M A
Department of Medical Genetics, University of Groningen, The Netherlands.
Genet Epidemiol. 1997;14(6):1125-30. doi: 10.1002/(SICI)1098-2272(1997)14:6<1125::AID-GEPI94>3.0.CO;2-I.
The number of identical deleterious mutations present in a population may become very large, depending on the combined effect of genetic drift, population growth and limited negative selection. The distribution of the length of the shared area between two random chromosomes carrying the mutations has been investigated for a number of generations varying from 20-100 since introduction. The consequences for investigations using association and haplotype sharing methods are discussed.
根据遗传漂变、种群增长和有限负选择的综合作用，种群中存在的相同有害突变数量可能会变得非常大。自引入突变以来，在20到100代不等的若干代中，对携带这些突变的两条随机染色体之间共享区域的长度分布进行了研究。讨论了使用关联和单倍型共享方法进行研究的后果。
