Section on Biostatistics, Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S81. doi: 10.1186/1471-2156-6-S1-S81.
This paper explores the decay of linkage disequilibrium (LD) on the autosomes and chromosome X. The extent of marker-marker LD is important for both linkage and association studies. The analysis of the Caucasian sample from the Collaborative Study on the Genetics of Alcoholism study revealed the expected negative relationship between the magnitude of the marker-marker LD and distance (cM), with the male and female subgroups exhibiting similar patterns of LD. The observed extent of LD in females was less across the pseudoautosomal markers relative to the heterosomal region of chromosome X. Marked differences in LD patterns were also observed between chromosomes X and the 22 autosomes in both males and females.
本文探讨了常染色体和 X 染色体上连锁不平衡（LD）的衰减。标记-标记 LD 的程度对连锁和关联研究都很重要。对来自酒精遗传协作研究的白种人样本的分析显示，标记-标记 LD 的程度与距离（厘摩）之间存在预期的负相关关系，男性和女性亚组表现出相似的 LD 模式。在女性中，相对于 X 染色体的异染色体区域，在假常染色体标记上观察到的 LD 程度较低。在男性和女性中，X 染色体和 22 条常染色体之间的 LD 模式也存在明显差异。
