基于多位点和相互作用的白种美国人酒精中毒风险因素的全基因组扫描：COGA 研究。

Multilocus and interaction-based genome scan for alcoholism risk factors in Caucasian Americans: the COGA study.

机构信息

Section on Biostatistics, Department of Public Health Sciences, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157-1063, USA.

出版信息

BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S37. doi: 10.1186/1471-2156-6-S1-S37.

DOI:10.1186/1471-2156-6-S1-S37

PMID:16451647

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1866748/

Abstract

In this paper, we applied the nonparametric linkage regression approach to the Caucasian genome scan data from the Collaborative Study on the Genetics of Alcoholism to search for regions of the genome that exhibit evidence for linkage to putative alcoholism-predisposing genes. The multipoint single-locus model identified four regions of the genome with LOD scores greater than one. These regions were on 7p near D7S1790 (LOD = 1.31), two regions on 7q near D7S1870 (LOD = 1.15) and D7S1799 (LOD = 1.13) and 21q near D21S1440 and D21S1446 (LOD = 1.78). Jointly modeling these loci provided stronger evidence for linkage in each of these regions (LOD = 1.58 on 7q11, LOD = 1.61 on 11q23, and LOD = 1.95 on 21q22). The evidence for linkage tended to increase among pedigrees with earlier mean age of onset at 8q23 (p = 0.0016), 14q21 (p = 0.0079), and 18p12 (p = 0.0021) and with later mean age of onset at 4q35 (p = 0.0067) and 9p22 (p = 0.0008).

摘要

在本文中，我们应用非参数连锁回归方法对来自酒精中毒遗传学合作研究的白种人基因组扫描数据进行分析，以寻找与假定的酒精中毒易感基因连锁的基因组区域。多点单基因模型确定了四个基因组区域的 LOD 得分大于 1。这些区域位于 7p 上，靠近 D7S1790（LOD = 1.31），7q 上的两个区域靠近 D7S1870（LOD = 1.15）和 D7S1799（LOD = 1.13），以及 21q 上靠近 D21S1440 和 D21S1446（LOD = 1.78）。联合建模这些基因座在每个区域都提供了更强的连锁证据（7q11 上的 LOD = 1.58，11q23 上的 LOD = 1.61，21q22 上的 LOD = 1.95）。连锁证据在具有更早平均发病年龄的家系中趋于增加，例如 8q23（p = 0.0016）、14q21（p = 0.0079）和 18p12（p = 0.0021），以及具有更晚平均发病年龄的家系中，例如 4q35（p = 0.0067）和 9p22（p = 0.0008）。