Glial fibrillary acidic protein expression after electroconvulsive shocks in rat brain.
作者信息
Ceresér Keila M, Frey Benício N, Bernardes Fernanda B, Costa Sabrina C, Andreazza Ana C, Feier Gustavo, Souza Daniela, Tramontina Francine, Gonçalves Carlos A, Kapczinski Flávio, Quevedo João
机构信息
Laboratório de Psiquiatria Experimental, Centro de Pesquisas, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2350, 90035-003 Porto Alegre, RS, Brazil.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jun;30(4):663-7. doi: 10.1016/j.pnpbp.2005.11.038. Epub 2006 Jan 31.
OBJECTIVE
The aim of the present study was to assess the effect of electroconvulsive shock (ECS) in glial fibrillary acidic protein (GFAP) expression in rat brain.
METHODS
Rats were given either a single (acute) or a series of eight (chronic) ECS. Brain regions were isolated and levels of glial fibrillary acidic protein (GFAP) in the brain tissue (cortex, hippocampus, and cerebellum) were assessed using an enzyme-linked immunosorbent assay (ELISA).
RESULTS
We showed that GFAP expression is reduced in the hippocampus within 48 h and 7 days after acute ECS. GFAP levels are increased in the cerebellum immediately after acute and chronic ECS. No changes were observed in the cortex.
CONCLUSIONS
Our findings showed a differential effect of acute and chronic ECS in the astroglial response in the brain of rats.
Zotero 插件