Franklin P J, Hall G L, Moeller A, Horak F, Brennan S, Stick S M
School of Paediatrics and Child Health, University of Western Australia, GPO Box D184, Perth, 6480, Western Australia.
Eur Respir J. 2006 Feb;27(2):350-3. doi: 10.1183/09031936.06.00071005.
Fractional exhaled nitric oxide (F(eNO)) has been reported to be reduced in cystic fibrosis (CF) patients. However, data from young children are conflicting and it is not clear whether this is a primary feature of the disease or a secondary response. The present study compared F(eNO) between CF and healthy infants using a validated single-breath technique. A total of 23 healthy infants (11 females; mean age 40.1 weeks) and 18 infants with CF (nine females; 64.9 weeks) underwent tests of lung function and F(eNO). Bronchoalveolar lavage (BAL) was collected from all CF infants 2-5 days after lung function testing. There was no significant difference in F(eNO) between the CF and healthy infants (geometric mean: 23.1 parts per billion (ppb) and 17.0 ppb, respectively). There was an inverse relationship between age and F(eNO) in the CF patients, but not in the healthy group. Within the CF group, there was no association between F(eNO) and any marker of airway inflammation measured in the BAL. Exhaled nitric oxide is not reduced in cystic fibrosis infants, but does decrease with age. The current data indicate that F(eNO) is not a good marker of airway inflammation in cystic fibrosis.
据报道，囊性纤维化（CF）患者的呼出一氧化氮分数（F（eNO））降低。然而，幼儿的数据存在矛盾，尚不清楚这是该疾病的主要特征还是次要反应。本研究使用经过验证的单次呼吸技术比较了CF婴儿和健康婴儿的F（eNO）。共有23名健康婴儿（11名女性；平均年龄40.1周）和18名CF婴儿（9名女性；64.9周）接受了肺功能和F（eNO）测试。在肺功能测试后2 - 5天，从所有CF婴儿中采集支气管肺泡灌洗（BAL）样本。CF婴儿和健康婴儿的F（eNO）之间无显著差异（几何平均值分别为23.1十亿分之一（ppb）和17.0 ppb）。CF患者中年龄与F（eNO）呈负相关，但健康组中并非如此。在CF组内，F（eNO）与BAL中测量的任何气道炎症标志物之间均无关联。囊性纤维化婴儿的呼出一氧化氮并未降低，但会随年龄增长而下降。目前的数据表明，F（eNO）不是囊性纤维化气道炎症的良好标志物。
