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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Lang F, Greger R, Deetjen P, Knox F G

Adv Exp Med Biol. 1977;76B:100-9. doi: 10.1007/978-1-4684-3285-5_14.

Urate transport in the rat appears to be saturable. However, affinity of the transport system for urate is very low and transport far from saturated at physiological plasma concentrations. 2. Since increase of the nonionized fraction of uric acid by a factor of five failed to increase urate reabsorption, transport cannot be due to nonionic diffusion but rather involves ionized urate. 3. Increases in luminal flow rate markedly depress urate reabsorption in the loop of Henle, which results in wash out of medullary urate.

大鼠体内的尿酸盐转运似乎具有饱和性。然而，该转运系统对尿酸盐的亲和力非常低，在生理血浆浓度下远未达到饱和。2. 由于尿酸非离子化部分增加五倍未能增加尿酸盐重吸收，所以转运并非由于非离子扩散，而是涉及离子化尿酸盐。3. 管腔流速增加会显著降低髓袢升支粗段对尿酸盐的重吸收，从而导致髓质尿酸盐被冲刷掉。

Lang F, Greger R, Deetjen P, Knox F G

Adv Exp Med Biol. 1977;76B:100-9. doi: 10.1007/978-1-4684-3285-5_14.

Urate transport in the rat appears to be saturable. However, affinity of the transport system for urate is very low and transport far from saturated at physiological plasma concentrations. 2. Since increase of the nonionized fraction of uric acid by a factor of five failed to increase urate reabsorption, transport cannot be due to nonionic diffusion but rather involves ionized urate. 3. Increases in luminal flow rate markedly depress urate reabsorption in the loop of Henle, which results in wash out of medullary urate.

大鼠体内的尿酸盐转运似乎具有饱和性。然而，该转运系统对尿酸盐的亲和力非常低，在生理血浆浓度下远未达到饱和。2. 由于尿酸非离子化部分增加五倍未能增加尿酸盐重吸收，所以转运并非由于非离子扩散，而是涉及离子化尿酸盐。3. 管腔流速增加会显著降低髓袢升支粗段对尿酸盐的重吸收，从而导致髓质尿酸盐被冲刷掉。