Kim Ji Hee, Oh Jae Keun, Wee Jee Hye, Min Chan Yang, Yoo Dae Myoung, Choi Hyo Geun
Department of Neurosurgery, Hallym University College of Medicine, Anyang 14068, Korea.
Department of Otorhinolaryngology, Hallym University College of Medicine, Anyang 14068, Korea.
Brain Sci. 2021 May 13;11(5):623. doi: 10.3390/brainsci11050623.
(1) Background: Controversy exists regarding the relationship between anemia and Parkinson's disease (PD). This study aimed to evaluate the risk of PD related to anemia in the Korean population. (2) Methods: The Korean National Health Insurance Service-National Sample Cohort, which includes adults over 40 years of age, was assessed from 2002 to 2015. A total of 5844 PD patients were matched by age, sex, income, and region of residence with 23,376 control participants at a ratio of 1:4. The analyzed covariates included age, sex, blood pressure, fasting blood glucose, obesity, smoking status, and alcohol consumption. A multiple logistic regression analysis was conducted for case-control analyses. (3) Results: The adjusted odds ratio (OR) for the risk of PD associated with anemia was 1.09 after adjusting for potential confounders (95% confidence interval (CI) 1.01-1.18, = 0.030). Among men younger than 70 years, the adjusted OR of PD was 1.34 (95% CI 1.13-1.60, = 0.001). (4) Conclusions: Our findings suggest that anemia may increase the risk of PD, particularly in men younger than 70 years. Further research is required to elucidate the causal relationship between these two diseases.
(1) 背景：贫血与帕金森病（PD）之间的关系存在争议。本研究旨在评估韩国人群中与贫血相关的帕金森病风险。(2) 方法：对韩国国民健康保险服务全国样本队列（包括40岁以上成年人）在2002年至2015年期间进行评估。共5844例帕金森病患者按年龄、性别、收入和居住地区与23376名对照参与者以1:4的比例进行匹配。分析的协变量包括年龄、性别、血压、空腹血糖、肥胖、吸烟状况和饮酒情况。进行病例对照分析的多因素logistic回归分析。(3) 结果：在调整潜在混杂因素后，与贫血相关的帕金森病风险的调整优势比（OR）为1.09（95%置信区间（CI）1.01 - 1.18，P = 0.030）。在70岁以下男性中，帕金森病的调整OR为1.34（95% CI 1.13 - 1.60，P = 0.001）。(4) 结论：我们的研究结果表明贫血可能增加帕金森病风险，尤其是在70岁以下男性中。需要进一步研究以阐明这两种疾病之间的因果关系。
