Cell Cycle Control Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX, School of Biological Sciences, University of Sussex, Falmer, Brighton, Sussex, BN1 6HG, UK.
EMBO J. 1986 Dec 1;5(12):3373-9. doi: 10.1002/j.1460-2075.1986.tb04653.x.
The gene suc1 encodes a product which suppresses certain temperature sensitive mutants of the cell cycle control gene cdc2 of Schizosaccharomyces pombe. Mutants in the suc1 gene or over-expression of its product leads to delays in mitotic and meiotic nuclear division. Deletion of the suc1 gene is lethal and generates some cells blocked in the cell cycle and others impaired in cellular growth. It is likely that the suc1 gene product binds and forms unstable complexes with the cdc2 protein kinase and with other proteins necessary for the cell cycle and cellular growth. suc1 may have a regulatory role in these processes.
suc1 基因编码的产物可抑制裂殖酵母细胞周期控制基因 cdc2 的某些温度敏感突变体。 suc1 基因突变或其产物过表达会导致有丝分裂和减数分裂核分裂延迟。 suc1 基因缺失是致死的,并导致一些细胞在细胞周期中被阻断,而另一些细胞则在细胞生长中受损。 suc1 基因产物可能与 cdc2 蛋白激酶及其它细胞周期和细胞生长所需的蛋白结合形成不稳定的复合物。 suc1 可能在这些过程中具有调节作用。