Adela Barón María, del Real Sara, Solano Liseti, Sánchez Jaeger Armando
Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Venezuela.
Arch Latinoam Nutr. 2005 Sep;55(3):245-51.
Soluble transferrin receptor (sTfR) is an effective tool for iron deficiency (ID) diagnosis, and unlike serum ferritin (SF) and others indicators, is not affected by acute phase response during inflammatory processes. In order to diagnose ID using sTfR as iron status indicator and to estimate its utility, a cross sectional, descriptive study was performed in 190 preschoolers of Valencia, Venezuela. sTfR and SF were assessed by enzimoimmunoassay; hemoglobin (Hb) by automated method, and parasitic infestation by stool examination. ID was defined as SF < 12 micro/L, iron deficient erythropoiesis as sTfR > 2.3 mg/L, and anemia as Hb < 11.0 g/dL and < 11.5 g/dL, according to age. Statistical analysis included descriptives, frequency distribution, chi2 and Spearman correlations. ID was highly prevalent as shown by serum ferritin (69.0%), sTfR (72.5%) and sTfR/FS ratio (81.9%). sTfR/FS ratio was more efficient in the ID diagnosis than any other indicator by itself. A high percentage of anemia was found (25.9%), from which, 79.5% was due to iron deficiency. No association to parasites was observed. It is concluded that sTfR is a useful tool for the diagnosis of iron deficiency and that a high nutritional risk for iron nutritional status. Low intake of high bio-available iron and poor socioeconomic conditions are important factors in this problem.
可溶性转铁蛋白受体（sTfR）是诊断缺铁（ID）的有效工具，与血清铁蛋白（SF）及其他指标不同，它不受炎症过程中急性期反应的影响。为了将sTfR作为铁状态指标诊断ID并评估其效用，在委内瑞拉巴伦西亚的190名学龄前儿童中开展了一项横断面描述性研究。采用酶免疫测定法评估sTfR和SF；采用自动化方法测定血红蛋白（Hb），通过粪便检查确定寄生虫感染情况。根据年龄，ID定义为SF<12微克/升，缺铁性红细胞生成定义为sTfR>2.3毫克/升，贫血定义为Hb<11.0克/分升（年龄相关）和<11.5克/分升。统计分析包括描述性统计、频率分布、卡方检验和Spearman相关性分析。血清铁蛋白显示ID的患病率很高（69.0%），sTfR（72.5%）和sTfR/FS比值（81.9%）。sTfR/FS比值在ID诊断中比任何其他单一指标更有效。发现贫血的比例很高（25.9%），其中79.5%是由缺铁引起的。未观察到与寄生虫的关联。结论是，sTfR是诊断缺铁的有用工具，且铁营养状况存在较高的营养风险。高生物利用度铁的摄入量低和社会经济条件差是该问题的重要因素。
