Caco-2细胞单层在预测肠道药物吸收中的作用。

Role of Caco-2 cell monolayers in prediction of intestinal drug absorption.

作者信息

Shah Pranav, Jogani Viral, Bagchi Tamishraha, Misra Ambikanandan

机构信息

Department of Pharmacy, Faculty of Technology & Engineering, The Maharaja Sayajirao University of Baroda, Post Box 51, Kalabhavan, Vadodara 390 001, India.

出版信息

Biotechnol Prog. 2006 Jan-Feb;22(1):186-98. doi: 10.1021/bp050208u.

DOI:10.1021/bp050208u

PMID:16454510

Abstract

The usefulness of Caco-2 cell monolayers in determining the intestinal drug absorption of potential drug candidates as such and from delivery systems, elucidating the underlying mechanisms thereof, presystemic metabolism, cellular uptake and cytotoxicological assessment has been exemplified in this review. The role of Caco-2 cell monolayers in studying the effectiveness, involved mechanism and toxicity of various excipients for drug absorption promotion has also been discussed.

摘要

本综述举例说明了Caco-2细胞单层在确定潜在候选药物本身及其从给药系统中的肠道药物吸收、阐明其潜在机制、系统前代谢、细胞摄取和细胞毒性评估方面的有用性。还讨论了Caco-2细胞单层在研究各种辅料促进药物吸收的有效性、涉及的机制和毒性方面的作用。