Singh Vibhuti, Deedwania Prakash
Cardiology Division, VACCHCS/UCSF, Fresno, CA 93703, USA.
Curr Atheroscler Rep. 2006 Jan;8(1):32-40. doi: 10.1007/s11883-006-0062-4.
Cardiovascular disease (CVD) is the leading cause of death in the United States, and certain population groups, such as South Asians, African Americans, and Hispanics, carry a disproportionately larger burden of CVD manifested as coronary artery disease, cerebrovascular disease, and hypertension. Persons of these special populations experience approximately two- to threefold greater morbidity and mortality. Prevalence of risk factors, including dyslipidemia, overweight, and diabetes, is not only higher in these groups, but is also rising. The reasons for such disparity appear to be multifactorial and influenced by such factors as lifestyle, diet, culture, genetics, and suboptimal healthcare. Furthermore, because these minority populations are not significantly represented in major clinical trials, evidence-based management strategies for treatment and prevention of CVD are seriously lacking. Lately, however, several randomized trials of therapy for dyslipidemia to reduce cardiovascular events among these ethnic groups have been undertaken. Preliminary data suggest the need for stricter goals and increasingly aggressive therapy for these special populations, including administrative and educational interventions.
心血管疾病（CVD）是美国的主要死因，某些人群，如南亚人、非裔美国人和西班牙裔，患心血管疾病的负担 disproportionately 更大，表现为冠状动脉疾病、脑血管疾病和高血压。这些特殊人群的发病率和死亡率大约高出两到三倍。包括血脂异常、超重和糖尿病在内的危险因素不仅在这些群体中更为普遍，而且还在上升。这种差异的原因似乎是多方面的，受到生活方式、饮食、文化、遗传和医疗保健不足等因素的影响。此外，由于这些少数族裔人群在主要临床试验中没有得到充分体现，严重缺乏基于证据的心血管疾病治疗和预防管理策略。然而，最近已经开展了几项针对血脂异常治疗以减少这些种族群体心血管事件的随机试验。初步数据表明，需要为这些特殊人群制定更严格的目标并采取更积极的治疗措施，包括行政和教育干预。
