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10. 特应性皮炎。

10. Atopic dermatitis.

作者信息

Boguniewicz Mark, Leung Donald Y M

机构信息

Division of Pediatric Allergy-Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Rm. J310, Denver, CO 80206, USA.

出版信息

J Allergy Clin Immunol. 2006 Feb;117(2 Suppl Mini-Primer):S475-80. doi: 10.1016/j.jaci.2005.10.018.

Abstract

Atopic dermatitis is a common chronic inflammatory skin disease often preceding the development of asthma and allergic disorders, such as food allergy or allergic rhinoconjunctivitis. Pathophysiology involves a complex series of interactions between resident and infiltrating cells orchestrated by proinflammatory cytokines and chemokines. A deficiency of antimicrobial peptides might contribute to the propensity for colonization or infection by microbial organisms seen in atopic dermatitis. New treatment approaches include use of topical steroids as maintenance therapy and use of topical calcineurin inhibitors for early intervention with topical steroids used as rescue therapy.

摘要

特应性皮炎是一种常见的慢性炎症性皮肤病,常先于哮喘和过敏性疾病(如食物过敏或变应性鼻结膜炎)的发生。其病理生理学涉及由促炎细胞因子和趋化因子精心安排的常驻细胞和浸润细胞之间一系列复杂的相互作用。抗菌肽的缺乏可能导致特应性皮炎中所见的微生物定植或感染倾向。新的治疗方法包括使用外用类固醇作为维持治疗,以及使用外用钙调神经磷酸酶抑制剂进行早期干预,外用类固醇用作急救治疗。

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