特应性皮炎的新认识及其对感染性并发症管理的影响。
Recent insights into atopic dermatitis and implications for management of infectious complications.
机构信息
Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine, 1400 Jackson St, Rm J310, Denver, CO 80206, USA.
出版信息
J Allergy Clin Immunol. 2010 Jan;125(1):4-13; quiz 14-5. doi: 10.1016/j.jaci.2009.11.027.
Abstract
Atopic dermatitis (AD) is a common complex disease that frequently follows a chronic relapsing course and affects the quality of life of patients and families in a significant manner. New insights into the pathophysiology of AD point to an important role of structural abnormalities in the epidermis combined with immune dysregulation. Patients with AD have a unique predisposition to colonization or infection by a number of microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. A multipronged approach directed at healing or protecting the skin barrier and addressing the immune dysregulation is necessary to improve the likelihood of successful outcomes.
摘要
特应性皮炎（AD）是一种常见的复杂疾病，常呈慢性反复发作过程，显著影响患者及其家庭的生活质量。AD 病理生理学的新认识提示表皮结构异常与免疫失调均发挥重要作用。AD 患者存在某些微生物定植或感染的独特易感性，最显著的是金黄色葡萄球菌和单纯疱疹病毒。需要采取多管齐下的方法来促进皮肤屏障的修复或保护，并解决免疫失调问题，以提高成功治疗的可能性。
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