特应性皮炎的当前管理与特应性进程的阻断

Current management of atopic dermatitis and interruption of the atopic march.

作者信息

Boguniewicz Mark, Eichenfield Lawrence F, Hultsch Thomas

机构信息

Division of Pediatric Allergy-Immunology, National Jewish Medical Research Center and University of Colorado School of Medicine, Denver, Colorado 80206, USA.

出版信息

J Allergy Clin Immunol. 2003 Dec;112(6 Suppl):S140-50. doi: 10.1016/j.jaci.2003.09.031.

DOI:10.1016/j.jaci.2003.09.031

PMID:14657844

Abstract

Treatment of atopic dermatitis requires a comprehensive approach that includes evaluation of potential triggers and education of the patient and family regarding proper avoidance measures. Hydration of the skin and maintenance of an intact skin barrier remain integral to proper management. Although topical corticosteroids have been a mainstay of anti-inflammatory therapy, the newer topical calcineurin inhibitors offer advantages for treatment of this chronic, relapsing disease. Studies aimed at defining optimal combination therapy and early intervention might change the treatment paradigm for atopic dermatitis.

摘要

特应性皮炎的治疗需要综合方法，包括评估潜在诱因以及对患者及其家属进行关于适当避免措施的教育。皮肤保湿和维持完整的皮肤屏障仍然是恰当管理的重要组成部分。虽然局部用皮质类固醇一直是抗炎治疗的主要手段，但新型局部用钙调神经磷酸酶抑制剂为治疗这种慢性复发性疾病提供了优势。旨在确定最佳联合治疗和早期干预的研究可能会改变特应性皮炎的治疗模式。