Ciprandi Giorgio, Cirillo Ignazio, Klersy Catherine, Vizzaccaro Andrea, Tosca Maria Angela, Marseglia Gian Luigi
Azienda Ospedaliera Universitaria San Martino, Genoa, Italy.
Otolaryngol Head Neck Surg. 2006 Feb;134(2):255-9. doi: 10.1016/j.otohns.2005.10.043.
The decongestion test involves spraying an intranasal vasoconstrictor drug to evaluate the recovery of nasal airflow.
The aim of this study was to assess the relationship between pulmonary function (assessed by spirometry and methacholine challenge) and nasal airflow recovery after a topical vasoconstrictor had been administered in patients with allergic rhinitis (perennial, seasonal, or mixed allergic rhinitis).
A total of 150 subjects were studied. The total symptom score, sensitization, and pulmonary function were all assessed. All subjects underwent rhinomanometry and the decongestion test.
Univariate analysis revealed that nasal symptoms and spirometric parameters (except FEF(25-75) in subjects with seasonal allergic rhinitis) were not. Only bronchial hyperreactivity, assessed by methacholine challenge, proved to be significantly (and independently) associated with outcome (OR 1.45, P = 0.025).
This study provides the first evidence of an association between a positive response to the decongestion test and bronchial hyperreactivity, assessed by methacholine challenge, in patients with allergic rhinitis.
减充血试验包括喷洒鼻内血管收缩药物以评估鼻气流的恢复情况。
本研究的目的是评估在患有过敏性鼻炎（常年性、季节性或混合性过敏性鼻炎）的患者中，在局部使用血管收缩剂后，肺功能（通过肺量计和乙酰甲胆碱激发试验评估）与鼻气流恢复之间的关系。
共研究了150名受试者。对总症状评分、致敏情况和肺功能进行了评估。所有受试者均接受了鼻阻力测量和减充血试验。
单因素分析显示，鼻症状和肺量计参数（季节性过敏性鼻炎患者的FEF(25 - 75)除外）并无关联。只有通过乙酰甲胆碱激发试验评估的支气管高反应性被证明与结果显著（且独立）相关（OR 1.45，P = 0.025）。
本研究首次提供了证据，表明在过敏性鼻炎患者中，减充血试验的阳性反应与通过乙酰甲胆碱激发试验评估的支气管高反应性之间存在关联。
