de Torres J P, Cordoba-Lanus E, López-Aguilar C, Muros de Fuentes M, Montejo de Garcini A, Aguirre-Jaime A, Celli B R, Casanova C
Unidad de Investigación, Hospital Nuestra Señora de Candelaria, Ctra del Rosario s/n, 38010 Santa Cruz de Tenerife, Canary Islands, Spain.
Eur Respir J. 2006 May;27(5):902-7. doi: 10.1183/09031936.06.00109605. Epub 2006 Feb 2.
The aim of this study was to determine the relationship between C-reactive protein (CRP) levels and factors known to predict outcome in stable chronic obstructive pulmonary disease (COPD) patients. The following were studied in 130 stable COPD patients: spirometry, lung volume, arterial oxygen tension (P(a,O2)), dyspnoea, 6-min walk distance (6MWD), body mass index, fat-free mass index, BODE (body mass index, obstruction, dyspnoea and exercise capacity), health-related quality of life, smoking status, the presence of cardiovascular risk factors or disease, corticosteroid use and number of exacerbations in the previous year. CRP levels were measured in these patients and in 65 controls. Using univariate and multivariate analyses, any possible association with the predictors of outcomes was evaluated. CRP levels were higher in COPD patients than in controls (4.1 versus 1.8 mg.L(-1), respectively). Correlation was found with the following variables: forced expiratory volume in one second (FEV1; -0.23), FEV1 % (-0.20), forced vital capacity (FVC; -0.24), FVC % (-0.24), Global Initiative for Chronic Obstructive Lung Disease stage (0.17), BODE (0.17), inspiratory capacity/total lung capacity (-0.20), P(a,O2) (-0.40) and 6MWD (-0.30). Using multivariate analysis, P(a,O2) and 6MWD manifested the strongest negative association with CRP levels. C-reactive protein levels in stable chronic obstructive pulmonary disease patients are best correlated with arterial oxygen tension and 6-min walk distance. This should be considered when C-reactive protein levels are measured in stable chronic obstructive pulmonary disease patients.
本研究的目的是确定C反应蛋白（CRP）水平与已知可预测稳定期慢性阻塞性肺疾病（COPD）患者预后的因素之间的关系。对130例稳定期COPD患者进行了以下研究：肺功能测定、肺容积、动脉血氧分压（P(a,O2)）、呼吸困难、6分钟步行距离（6MWD）、体重指数、去脂体重指数、BODE指数（体重指数、气流受限、呼吸困难和运动能力）、健康相关生活质量、吸烟状况、心血管危险因素或疾病的存在、皮质类固醇使用情况以及上一年的急性加重次数。对这些患者和65名对照者测定了CRP水平。采用单因素和多因素分析，评估与预后预测指标的任何可能关联。COPD患者的CRP水平高于对照组（分别为4.1和1.8 mg.L(-1)）。发现与以下变量存在相关性：一秒用力呼气容积（FEV1；-0.23）、FEV1%（-0.20）、用力肺活量（FVC；-0.24）、FVC%（-0.24）、慢性阻塞性肺疾病全球倡议（GOLD）分级（0.17）、BODE指数（0.17）、吸气容积/肺总量（-0.20）、P(a,O2)（-0.40）和6MWD（-0.30）。多因素分析显示，P(a,O2)和6MWD与CRP水平呈最强的负相关。稳定期慢性阻塞性肺疾病患者的C反应蛋白水平与动脉血氧分压和6分钟步行距离的相关性最佳。在对稳定期慢性阻塞性肺疾病患者测定C反应蛋白水平时应考虑这一点。
