Liang Xiaopeng, Chou Oscar Hou In, Cheung Bernard My
Division of Clinical Pharmacology and Therapeutics, Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.
State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pokfulam, Hong Kong, China.
Chronic Obstr Pulm Dis. 2023 Apr 27;10(2):190-198. doi: 10.15326/jcopdf.2022.0306.
Systemic arterial hypertension (HTN) is one of the common comorbidities among patients with chronic obstructive pulmonary disease (COPD). This study aimed to investigate the association between HTN and COPD.
A total of 46,804 eligible non-pregnant participants aged ≥ 20 years examined in the Mobile Examination Center of the National Health and Nutrition Examination Survey (NHANES) 1999-2018 were included in this cross-sectional study. Participants with invalid data on covariates, HTN, and COPD were excluded. The association between HTN and COPD was studied using logistic regression upon adjusting the potential covariates.
Among the participants, 46.1% (95% confidence interval [CI], 45.3-46.9) had HTN, and 6.8% (95% CI, 6.4-7.2) had self-reported COPD. COPD was associated with HTN (OR [odds ratio]=1.18, 95% CI [1.05-1.31], <0.01) after adjusting for demographics, socioeconomic factors, smoking, diabetes, body mass index, and medication use, including inhaled corticosteroids and methylxanthines. The association between HTN and COPD was significant among adults younger than 60 years (<0.01). Stratified by smoking status, there was a significant association between HTN and COPD in current heavy smokers (1.25, 95% CI [1.01-1.58]; =0.04).
In this nationwide survey, COPD was associated with HTN. The association was more robust among adults younger than 60 years and current heavy smokers. Future prospective studies are needed to examine the relationship between HTN and COPD.
系统性动脉高血压（HTN）是慢性阻塞性肺疾病（COPD）患者常见的合并症之一。本研究旨在探讨HTN与COPD之间的关联。
本横断面研究纳入了1999 - 2018年美国国家健康与营养检查调查（NHANES）移动检查中心检查的46804名年龄≥20岁的合格非妊娠参与者。排除协变量、HTN和COPD数据无效的参与者。在调整潜在协变量后，使用逻辑回归研究HTN与COPD之间的关联。
在参与者中，46.1%（95%置信区间[CI]，45.3 - 46.9）患有HTN，6.8%（95%CI，6.4 - 7.2）自述患有COPD。在调整人口统计学、社会经济因素、吸烟、糖尿病、体重指数和药物使用（包括吸入性糖皮质激素和甲基黄嘌呤）后，COPD与HTN相关（比值比[OR]=1.18，95%CI[1.05 - 1.31]，P<0.01）。HTN与COPD之间的关联在60岁以下成年人中显著（P<0.01）。按吸烟状况分层，当前重度吸烟者中HTN与COPD之间存在显著关联（1.25，95%CI[1.01 - 1.58]；P = 0.04）。
在这项全国性调查中，COPD与HTN相关。这种关联在60岁以下成年人和当前重度吸烟者中更为明显。未来需要进行前瞻性研究以检验HTN与COPD之间的关系。
