Masopust David, Vezys Vaiva, Wherry E John, Barber Daniel L, Ahmed Rafi
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
J Immunol. 2006 Feb 15;176(4):2079-83. doi: 10.4049/jimmunol.176.4.2079.
Whether tissue microenvironment influences memory CD8 T cell differentiation is unclear. We demonstrate that virus-specific intraepithelial lymphocytes in gut resemble neither central nor effector memory CD8 T cells isolated from spleen or blood. This unique phenotype arises in situ within the gut, suggesting that anatomic location plays an inductive role in the memory differentiation program. In support of this hypothesis, memory CD8 T cells changed phenotype upon change in location. After transfer and in vivo restimulation, gut or spleen memory cells proliferated, disseminated into spleen and gut, and adopted the memory T cell phenotype characteristic of their new environment. Our data suggests that anatomic location directly impacts the memory T cell differentiation program.
组织微环境是否影响记忆性CD8 T细胞分化尚不清楚。我们证明，肠道中的病毒特异性上皮内淋巴细胞既不像从脾脏或血液中分离出的中枢记忆性CD8 T细胞，也不像效应记忆性CD8 T细胞。这种独特的表型在肠道内原位产生，表明解剖位置在记忆分化程序中起诱导作用。为支持这一假设，记忆性CD8 T细胞在位置改变时会改变表型。转移并在体内重新刺激后，肠道或脾脏记忆细胞增殖，扩散到脾脏和肠道，并呈现其新环境特有的记忆性T细胞表型。我们的数据表明，解剖位置直接影响记忆性T细胞分化程序。
