Levy J A, Hartley J W, Rowe W P, Huebner R J
J Natl Cancer Inst. 1975 Mar;54(3):615-9.
A high-titered non-focus-forming virus, FBJ-MuLV (murine leukemia virus), present in FBJ tumor preparations, inhibited significantly the expression and production of FBJ-MuSV (murine sarcoma virus) in tissue culture. This "autoinhibition" was comparable to that observed when a 3- to 4-log excess of infectious MuLV was added to standard MuSV. The degree of inhibition was influenced by the tropism of the MuLV (or the ease of spread and propagation of MuLV in certain cells), multiplicity of infection by MuLV, amount of excess MuLV, and ability of the MuSV-transformed cells to replicate independently. The FBJ MuLV-MuSV complex may be a model system for the detection of sarcoma viruses in spontaneous tumors in various animals where inhibition by excess nontransforming virus could be an important biologic phenomenon.
存在于FBJ肿瘤制剂中的一种高滴度非聚焦形成病毒，即FBJ-莫洛尼鼠白血病病毒（murine leukemia virus, FBJ-MuLV），在组织培养中显著抑制了FBJ-莫洛尼鼠肉瘤病毒（murine sarcoma virus, FBJ-MuSV）的表达和产生。这种“自身抑制”与向标准MuSV中添加3至4个对数过量的感染性MuLV时所观察到的情况相当。抑制程度受MuLV的嗜性（或MuLV在某些细胞中的传播和增殖难易程度）、MuLV的感染复数、过量MuLV的量以及MuSV转化细胞独立复制能力的影响。FBJ MuLV-MuSV复合体可能是用于检测各种动物自发肿瘤中肉瘤病毒的模型系统，其中过量非转化病毒的抑制可能是一种重要的生物学现象。
