蛋白酪氨酸磷酸酶非受体型22（PTPN22）基因R620W变异与银屑病关节炎的男性受限遗传关联。 - Suppr

Male restricted genetic association of variant R620W in PTPN22 with psoriatic arthritis.

作者信息

Hüffmeier Ulrike, Reis André, Steffens Michael, Lascorz Jesús, Böhm Beate, Lohmann Jörg, Wendler Jörg, Traupe Heiko, Küster Wolfgang, Wienker Thomas F, Burkhardt Harald

出版信息

J Invest Dermatol. 2006 Apr;126(4):932-5. doi: 10.1038/sj.jid.5700179.

DOI:10.1038/sj.jid.5700179

PMID:16456530

Abstract

摘要

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Male restricted genetic association of variant R620W in PTPN22 with psoriatic arthritis.蛋白酪氨酸磷酸酶非受体型22（PTPN22）基因R620W变异与银屑病关节炎的男性受限遗传关联。

J Invest Dermatol. 2006 Apr;126(4):932-5. doi: 10.1038/sj.jid.5700179.

Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study.银屑病关节炎中PTPN22和tp53功能变异的关联：一项病例对照研究。

Arthritis Res Ther. 2006;8(1):R27. doi: 10.1186/ar1880. Epub 2006 Jan 3.

The protein tyrosine phosphatase, non-receptor type 22 R620W polymorphism does not confer susceptibility to psoriasis in the genetic homogeneous population of Crete.蛋白酪氨酸磷酸酶非受体型22的R620W多态性在克里特岛基因同质人群中不会导致银屑病易感性。

Genet Test Mol Biomarkers. 2010 Feb;14(1):107-11. doi: 10.1089/gtmb.2009.0130.

The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status.蛋白酪氨酸磷酸酶非受体型22（PTPN22）基因R620W多态性与类风湿因子（RF）阳性类风湿关节炎呈剂量依赖性相关，但与人类白细胞抗原SE（HLA-SE）状态无关。

Genes Immun. 2005 Mar;6(2):129-33. doi: 10.1038/sj.gene.6364159.

Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.在加拿大人群中，淋巴样酪氨酸磷酸酶R620W变体与类风湿性关节炎相关，但与克罗恩病无关。

Arthritis Rheum. 2005 Jul;52(7):1993-8. doi: 10.1002/art.21123.

Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population.法国白种人群中蛋白酪氨酸磷酸酶非受体22（PTPN22）*620W等位基因与系统性硬化症之间不存在关联。

Ann Rheum Dis. 2006 Sep;65(9):1230-2. doi: 10.1136/ard.2005.048181. Epub 2006 Feb 7.

Confirmation of the association of the R620W polymorphism in the protein tyrosine phosphatase PTPN22 with type 1 diabetes in a family based study.在一项基于家系的研究中，证实蛋白酪氨酸磷酸酶PTPN22中R620W多态性与1型糖尿病的关联。

J Med Genet. 2005 Mar;42(3):266-70. doi: 10.1136/jmg.2004.026971.

Lack of association between ankylosing spondylitis and a functional polymorphism of PTPN22 proposed as a general susceptibility marker for autoimmunity.强直性脊柱炎与被认为是自身免疫通用易感性标志物的蛋白酪氨酸磷酸酶非受体型22（PTPN22）功能多态性之间不存在关联。

Ann Rheum Dis. 2006 May;65(5):687-8. doi: 10.1136/ard.2005.046094. Epub 2005 Sep 8.

PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits.1型糖尿病及自身免疫相关性状中的PTPN22 R620W功能变异体

Diabetes. 2007 Feb;56(2):522-6. doi: 10.2337/db06-0942.

The PTPN22*R620W polymorphism does not confer genetic susceptibility to antiphospholipid syndrome in the Spanish population.该 PTPN22*R620W 多态性不能在西班牙人群中赋予抗磷脂综合征的遗传易感性。

Int J Immunogenet. 2011 Dec;38(6):529-31. doi: 10.1111/j.1744-313X.2011.01038.x. Epub 2011 Sep 19.

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Transcriptome Profiling Analyses in Psoriasis: A Dynamic Contribution of Keratinocytes to the Pathogenesis.银屑病的转录组谱分析：角质形成细胞对发病机制的动态贡献。

Genes (Basel). 2020 Sep 30;11(10):1155. doi: 10.3390/genes11101155.

HLA-C*06:02-independent, gender-related association of PSORS1C3 and PSORS1C1/CDSN single-nucleotide polymorphisms with risk and severity of psoriasis.HLA-C*06:02 非依赖性、性别相关的 PSORS1C3 和 PSORS1C1/CDSN 单核苷酸多态性与银屑病风险和严重程度的关联。

Mol Genet Genomics. 2018 Aug;293(4):957-966. doi: 10.1007/s00438-018-1435-4. Epub 2018 Mar 27.

Association of juvenile idiopathic arthritis with PTPN22 rs2476601 is specific to females in a Greek population.在希腊人群中，青少年特发性关节炎与PTPN22基因rs2476601的关联仅在女性中存在。

Pediatr Rheumatol Online J. 2016 Apr 23;14(1):25. doi: 10.1186/s12969-016-0087-3.

Identifying a novel locus for psoriatic arthritis.确定银屑病关节炎的一个新基因座。

Rheumatology (Oxford). 2016 Jan;55(1):25-32. doi: 10.1093/rheumatology/kev273. Epub 2015 Aug 8.

PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus.蛋白酪氨酸磷酸酶非受体型22（PTPN22）与银屑病关节炎易感性相关，但与银屑病无关：进一步证明存在银屑病关节炎特异性风险位点。

Ann Rheum Dis. 2015 Oct;74(10):1882-5. doi: 10.1136/annrheumdis-2014-207187. Epub 2015 Apr 28.

Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.酪氨酸磷酸酶PTPN22：免疫信号传导、发育和疾病的多功能调节因子。

Annu Rev Immunol. 2014;32:83-119. doi: 10.1146/annurev-immunol-032713-120249. Epub 2013 Dec 18.

Clinical differences between men and women with psoriatic arthritis: relevance of the analysis of genes and polymorphisms in the major histocompatibility complex region and of the age at onset of psoriasis.银屑病关节炎男性与女性的临床差异：主要组织相容性复合体区域基因及多态性分析与银屑病发病年龄的相关性

Clin Dev Immunol. 2013;2013:482691. doi: 10.1155/2013/482691. Epub 2013 Apr 16.

Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity.酪氨酸磷酸酶对 TCR 信号的调节：从免疫稳态到自身免疫。

Immunology. 2012 Sep;137(1):1-19. doi: 10.1111/j.1365-2567.2012.03591.x.

PTPN22 C1858T and the risk of psoriasis: a meta-analysis.PTPN22 C1858T 与银屑病风险：荟萃分析。

Mol Biol Rep. 2012 Aug;39(8):7861-70. doi: 10.1007/s11033-012-1630-z. Epub 2012 Apr 28.

Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.在一个大型银屑病关节炎队列中全面评估类风湿关节炎易感基因座。

Ann Rheum Dis. 2012 Aug;71(8):1350-4. doi: 10.1136/annrheumdis-2011-200802. Epub 2012 Feb 10.

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Male restricted genetic association of variant R620W in PTPN22 with psoriatic arthritis.

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