Queiro Rubén, Tejón Patricia, Coto Pablo, Alonso Sara, Alperi Mercedes, Sarasqueta Cristina, González Segundo, Martínez-Borra Jesús, López-Larrea Carlos, Ballina Javier
Rheumatology Department, Hospital Universitario Central de Asturias, C/Celestino Villamil s/n, Oviedo, 33006 Asturias, Spain.
Clin Dev Immunol. 2013;2013:482691. doi: 10.1155/2013/482691. Epub 2013 Apr 16.
It has been shown that males with spondyloarthritis tend to suffer from more severe spinal disease while females are more likely to have peripheral joint involvement. Nevertheless, gender-related differences have not been thoroughly explored in psoriatic arthritis (PsA). In PsA, males accumulate more peripheral and axial joint damage compared to women. However, it is not clear whether these findings are secondary to differences in occupational physical activity, hormonal changes, or other factors. The present study analyzed the differences in clinical expression of PsA between men and women. We have also evaluated the possible existence of gender-linked differences in the distribution of genes and polymorphisms within the major histocompatibility complex and whether patients' age at the onset of psoriasis established any differences in these aspects. Women suffered more polyarthritis, greater functional impairment, and a larger number of swollen joints during followup. We appreciated a differential expression of certain MHC genes according to gender and age at onset of psoriasis. Our results point to the need to include patient's age at the onset of psoriasis and gender as key stratification elements in future studies of genetic associations in PsA.
研究表明，患有脊柱关节炎的男性往往患有更严重的脊柱疾病，而女性更易出现外周关节受累。然而，银屑病关节炎（PsA）中与性别相关的差异尚未得到充分研究。在PsA中，男性比女性积累更多的外周和轴向关节损伤。然而，尚不清楚这些发现是否继发于职业体力活动、激素变化或其他因素的差异。本研究分析了男性和女性PsA临床表型的差异。我们还评估了主要组织相容性复合体中基因和多态性分布是否存在性别相关差异，以及银屑病发病时患者的年龄在这些方面是否存在差异。随访期间，女性患多关节炎的情况更多，功能损害更大，肿胀关节数量更多。我们发现某些MHC基因根据银屑病发病时的性别和年龄存在差异表达。我们的结果表明，在未来PsA遗传关联研究中，需要将银屑病发病时患者的年龄和性别作为关键分层因素。
