Horikoshi T, Sekiguchi T, Kusano M, Matsuzaki T
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
Gastroenterol Jpn. 1991 Apr;26(2):145-50. doi: 10.1007/BF02811072.
The effects of famotidine on human upper gastrointestinal motility were investigated, together with the relationship of gastric alkalinization and serum gastrin levels to changes produced by famotidine. Intravenous famotidine (20 mg), at a dose level in which an inhibitory effect on acetylcholinesterase activity is not recognized, was given to 13 patients with progressive systemic sclerosis but no other disorders. Gastric phasic motor activity was not changed significantly, but the lower esophageal sphincter pressure was elevated significantly in comparison with 15 controls given physiological saline, even when gastric phasic motor activity was taken into consideration. Gastric alkalinization with 7% sodium bicarbonate did not significantly increase the sphincter pressure in all 7 subjects so treated. No significant correlation was recognized between the serum gastrin level, the lower esophageal sphincter pressure, and the gastric motility index in any of the 3 groups. It was, therefore, concluded that intravenous administration of famotidine affected upper gastrointestinal motility, especially the lower esophageal sphincter pressure, through an as yet unknown mechanism other than inhibition of acetylcholinesterase activity, gastric alkalinization, or elevation of serum gastrin levels.
研究了法莫替丁对人上消化道运动的影响，以及胃碱化和血清胃泌素水平与法莫替丁产生的变化之间的关系。对13例进行性系统性硬化症且无其他疾病的患者静脉注射法莫替丁（20mg），该剂量水平未发现对乙酰胆碱酯酶活性有抑制作用。与15例给予生理盐水的对照相比，即使考虑胃的相性运动活动，胃的相性运动活动也无显著变化，但食管下括约肌压力显著升高。用7%碳酸氢钠使胃碱化，在所有7例接受治疗的受试者中，并未显著增加括约肌压力。在3组中的任何一组中，血清胃泌素水平、食管下括约肌压力和胃运动指数之间均未发现显著相关性。因此，得出结论，静脉注射法莫替丁通过一种尚未明确的机制影响上消化道运动，尤其是食管下括约肌压力，该机制并非抑制乙酰胆碱酯酶活性、胃碱化或血清胃泌素水平升高。
