Paradowski L, Salomon A, Szelag A
Katedry i Kliniki Gastroenterologii AM we Wroclawiu.
Pol Tyg Lek. 1996 Apr;51(14-18):227-9.
An effect of cimetidine and famotidine on the lower esophagus sphincter pressure and esophageal body motility has been investigated. The studies involved 30 patients with duodenal ulcer. The lower esophagus sphincter pressure, mean force and mean duration of spasms as well as wave transmission velocity in esophageal body, 1-13 cm above the sphincter, have been recorded with Polyphysiograph R-611. The lower esophagus sphincter pressure and esophageal body motility have been recorded 15 minutes prior to and following the administration of 200 mg cimetidine or 20 mg famotidine. It was shown that cimetidine has net changed the lower esophagus sphincter pressure and esophageal body motility parameters. Famotidine increased the lower esophagus sphincter pressure from the initial 2.31 +/- 1.19 kPa to 3.51 +/- 1.61 kPa (p < 0.05) and had no effect on the esophageal body motility parameters. It may be concluded that within H2-receptor antagonists famotidine may be considered a drug of choice in the treatment of gastroesophageal reflux.
已对西咪替丁和法莫替丁对食管下括约肌压力及食管体部运动的影响进行了研究。研究涉及30例十二指肠溃疡患者。使用R - 611多生理记录仪记录了食管下括约肌压力、痉挛的平均力量和平均持续时间，以及括约肌上方1 - 13厘米处食管体部的波传播速度。在给予200毫克西咪替丁或20毫克法莫替丁之前和之后15分钟记录食管下括约肌压力和食管体部运动情况。结果显示，西咪替丁未改变食管下括约肌压力和食管体部运动参数。法莫替丁使食管下括约肌压力从初始的2.31±1.19千帕增加到3.51±1.61千帕（p<0.05），且对食管体部运动参数无影响。可以得出结论，在H2受体拮抗剂中，法莫替丁可被视为治疗胃食管反流的首选药物。
