Pesatori Angela Cecilia, Mensi Carolina
Department of Occupational Health, University of Milan, Italy.
Med Lav. 2005 Jul-Aug;96(4):354-9.
The "Lombardy Mesothelioma Registry" started its activity in 2000 in accordance with Italian law DL 277/91.
The Registry collects all new incident cases of Malignant Mesothelioma (MM) of pleura, peritoneum, pericardium and vaginal tunic of testis occurring in residents in the Lombardy Region (Northern Italy). For each "possible case" reported to the Registry by Lombardy hospitals, diagnosis is ascertained according to ISPESL Guidelines. For confirmed cases, a standardized questionnaire is administered to the subject or next-of-kin, to verify sources of lifetime asbestos exposure. Descriptive results are given for cases collected in 2000-2001. Age standardized incidence rates for the year 2000 were calculated for males and females.
After revision of clinical records, diagnosis was judged as "certain" MM in 307 (60%) subjects, probable in 63 (12%) and possible in 33 (6%) subjects. 21 were peritoneal mesothelioma. Standardized rates for pleural mesothelioma were respectively 3.7 and 1.4 per 100,000 for males and females. Occupational asbestos exposure was ascertained for 71% of male cases and 26% of females. Exposure was unknown in 11% and 27% of males and females respectively. The main relevant exposures were in building trades, metal manufacturing, machine production and maintenance; an unexpectedly high proportion of female cases was engaged in non-asbestos textile factories.
The high proportion of cases with unknown exposure underlines the need to explore new tools and sources to ascertain asbestos exposure. An ad hoc survey in textile industries showed exposure to asbestos to be widely spread in this industry.
“伦巴第间皮瘤登记处”于2000年依据意大利第277/91号法律开始运作。
该登记处收集伦巴第地区（意大利北部）居民中发生的胸膜、腹膜、心包膜及睾丸鞘膜恶性间皮瘤（MM）的所有新发病例。对于伦巴第各医院向登记处报告的每一例“可能病例”，均依据意大利国家职业卫生与安全研究所（ISPESL）指南进行确诊。对于确诊病例，向患者本人或其近亲发放标准化问卷，以核实终生石棉暴露源。给出了2000 - 2001年收集病例的描述性结果。计算了2000年男性和女性的年龄标准化发病率。
经临床记录复查，307例（60%）患者的诊断被判定为“确诊”MM，63例（12%）为“可能”，33例（6%）为“疑似”。21例为腹膜间皮瘤。胸膜间皮瘤的标准化发病率男性为每10万人3.7例，女性为每10万人1.4例。71%的男性病例和26%的女性病例确定有职业性石棉暴露。男性和女性分别有11%和27%的暴露情况不明。主要相关暴露行业为建筑行业、金属制造、机械生产与维修；女性病例中从事非石棉纺织工厂工作的比例意外较高。
暴露情况不明的病例比例较高，凸显了探索确定石棉暴露的新工具和新来源的必要性。对纺织行业进行的专项调查显示，该行业石棉暴露情况广泛存在。
