Mensi Carolina, Termine Lorenzo, Canti Zulejka, Rivolta Giuseppe, Riboldi Luciano, Pesatori Angela Cecilia, Chiappino Gerolamo
Dipartimento di medicina preventiva, ambientale e del lavoro, Fondazione IRCCS-Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano.
Epidemiol Prev. 2007 Sep-Oct;31(5):283-9.
The Lombardy Mesothelioma Register (LMR) collects all incident cases of Malignant Mesothelioma (MM) occurring since January 1, 2000 in residents of the Lombardy Region. For each "possible case" reported to the Registry by Lombardy hospitals, diagnosis is ascertained through examination of clinical records (including histology reports) according to ISPESL Guidelines. For confirmed cases, a standardized questionnaire is administered to the subject or next-of-kin in order to verify the possible sources of asbestos exposure in his/her lifetime. A panel composed of industrial hygienists, occupational health physicians and occupational epidemiologists evaluate asbestos exposure in the workplace and environmental settings. Case ascertainment completeness is routinely verified using other sources such as hospital discharge records and death certificates coded as 163 (ICD IX). In the period 2000-2004, 1563 cases were collected, of whom 887 have been evaluated: the diagnosis was confirmed for 626 (70.6%) 9 out of 887 evaluated cases. The age and gender standardized incidence rate for pleural mesothelioma in the Lombardy Region, in the year 2000 (the only one with completed data), was 2.4 (males 3.7; females 1.4) per 100,000 residents/year The 70.5% of certain and probable MM has an asbestos exposure, in particular the 64.5% of cases has an occupational exposure. The experience gathered over the years by the LMR has allowed to implement an efficient information network among different institutions and health services. In addition practical skills have been gained in processing epidemiological data, a useful tool to address new scientific hypothesis and to plan ad-hoc researches. In our experience the LMR represents a potential resource transferable to the epidemiological surveillance of different occupational tumours (i.e. sino-nasal cancers).
伦巴第间皮瘤登记处（LMR）收集了自2000年1月1日以来伦巴第地区居民中发生的所有恶性间皮瘤（MM）新发病例。对于伦巴第地区医院向登记处报告的每一例“可能病例”，根据意大利国家社会保险局（ISPESL）指南，通过检查临床记录（包括组织学报告）来确定诊断。对于确诊病例，会向患者本人或其近亲发放一份标准化问卷，以核实其一生中可能的石棉接触源。由工业卫生学家、职业健康医生和职业流行病学家组成的小组评估工作场所和环境中的石棉接触情况。病例确诊的完整性会定期通过其他来源进行核实，如医院出院记录和编码为163（国际疾病分类第九版）的死亡证明。在2000 - 2004年期间，共收集了1563例病例，其中887例已进行评估：在887例评估病例中，626例（70.6%）确诊。2000年（唯一数据完整的年份）伦巴第地区胸膜间皮瘤的年龄和性别标准化发病率为每10万居民/年2.4（男性3.7；女性1.4）。70.5%的确诊和可能的MM有石棉接触史，特别是64.5%的病例有职业接触史。多年来LMR积累的经验使其能够在不同机构和卫生服务部门之间建立一个高效的信息网络。此外，在处理流行病学数据方面也获得了实用技能，这是应对新科学假设和规划专项研究的有用工具。根据我们的经验，LMR是一种可转移到不同职业肿瘤（如鼻窦癌）流行病学监测中的潜在资源。
