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1
Vasopressin-stimulated phosphoinositide hydrolysis in cultured rat inner medullary collecting duct cells is mediated by the oxytocin receptor.血管加压素刺激培养的大鼠髓质内集合管细胞中的磷酸肌醇水解是由催产素受体介导的。
J Clin Invest. 1991 Jun;87(6):2122-6. doi: 10.1172/JCI115243.
2
V2-like vasopressin receptor mobilizes intracellular Ca2+ in rat medullary collecting tubules.V2 样血管加压素受体可动员大鼠髓质集合管中的细胞内钙离子。
Am J Physiol. 1993 Jul;265(1 Pt 2):F35-45. doi: 10.1152/ajprenal.1993.265.1.F35.
3
Vasopressin and oxytocin receptors coupled to Ca2+ mobilization in rat inner medullary collecting duct.血管加压素和催产素受体与大鼠内髓集合管中的钙离子动员偶联。
Am J Physiol. 1993 Jul;265(1 Pt 2):F15-25. doi: 10.1152/ajprenal.1993.265.1.F15.
4
Vasopressin and oxytocin receptors on plasma membranes from rat mammary gland. Demonstration of vasopressin receptors by stimulation of inositol phosphate formation, and oxytocin receptors by binding of a specific 125I-labeled oxytocin antagonist, d(CH2)5(1)[Tyr(Me)2, Thr4,Tyr-NH2(9)]OVT.大鼠乳腺质膜上的血管升压素和催产素受体。通过刺激肌醇磷酸形成来证明血管升压素受体，通过特异性125I标记的催产素拮抗剂d(CH2)5(1)[Tyr(Me)2, Thr4,Tyr-NH2(9)]OVT的结合来证明催产素受体。
Biochem Cell Biol. 1989 Feb-Mar;67(2-3):152-62. doi: 10.1139/o89-023.
5
Separate receptors mediate oxytocin and vasopressin stimulation of cAMP in rat inner medullary collecting duct cells.在大鼠肾内髓集合管细胞中，催产素和加压素对环磷酸腺苷（cAMP）的刺激作用由不同的受体介导。
Exp Physiol. 1999 Jan;84(1):17-25. doi: 10.1111/j.1469-445x.1999.tb00068.x.
6
[Arginine]vasopressin hydrolyses phosphoinositides in the medullary thick ascending limb of mouse nephron.[精氨酸]血管加压素可水解小鼠肾单位髓质厚升支中的磷酸肌醇。
Pflugers Arch. 1993 Dec;425(5-6):381-9. doi: 10.1007/BF00374862.
7
Pharmacological characterization of V1a vasopressin receptors in the rat cortical collecting duct.大鼠皮质集合管中V1a血管加压素受体的药理学特性
Am J Physiol. 1992 Apr;262(4 Pt 2):F546-53. doi: 10.1152/ajprenal.1992.262.4.F546.
8
AVP stimulates adenylyl cyclase and phospholipase C in reciprocal fashion in cultured RIMCT cells.血管加压素（AVP）以相反的方式刺激培养的肾小管间质肌成纤维细胞（RIMCT细胞）中的腺苷酸环化酶和磷脂酶C。
Am J Physiol. 1990 Oct;259(4 Pt 1):C693-6. doi: 10.1152/ajpcell.1990.259.4.C693.
9
Vasopressin-induced nitric oxide production in rat inner medullary collecting duct is dependent on V2 receptor activation of the phosphoinositide pathway.血管加压素诱导大鼠髓质内集合管产生一氧化氮依赖于磷酸肌醇途径的V2受体激活。
Am J Physiol Renal Physiol. 2007 Aug;293(2):F526-32. doi: 10.1152/ajprenal.00052.2007. Epub 2007 May 16.
10
Receptors for neurohypophyseal hormones along the rat nephron: 125I-labelled d(CH2)5[Tyr(Me)2, Thr4, Orn8, Tyr-NH(2)9] vasotocin binding in microdissected tubules.大鼠肾单位中神经垂体激素的受体：在显微解剖的肾小管中125I标记的d(CH2)5[Tyr(Me)2, Thr4, Orn8, Tyr-NH(2)9]加压素结合
Pflugers Arch. 1991 Apr;418(3):220-7. doi: 10.1007/BF00370519.

引用本文的文献

1
Different localization and regulation of two types of vasopressin receptor messenger RNA in microdissected rat nephron segments using reverse transcription polymerase chain reaction.采用逆转录聚合酶链反应对显微切割的大鼠肾单位节段中两种血管加压素受体信使核糖核酸进行不同定位及调控研究
J Clin Invest. 1993 Nov;92(5):2339-45. doi: 10.1172/JCI116838.
2
Molecular analysis of vasopressin receptors in the rat nephron. Evidence for alternative splicing of the V2 receptor.大鼠肾单位中血管加压素受体的分子分析。V2受体选择性剪接的证据。
Pflugers Arch. 1994 Nov;429(1):79-89. doi: 10.1007/BF02584033.
3
Immunohistochemical localization of V2 vasopressin receptor along the nephron and functional role of luminal V2 receptor in terminal inner medullary collecting ducts.血管升压素V2受体在肾单位中的免疫组织化学定位及管腔V2受体在终末内髓集合管中的功能作用
J Clin Invest. 1995 Oct;96(4):1768-78. doi: 10.1172/JCI118222.
4
Feedback inhibition of cyclic adenosine monophosphate-stimulated Na+ transport in the rabbit cortical collecting duct via Na(+)-dependent basolateral Ca++ entry.通过依赖钠的基底外侧钙离子内流对家兔皮质集合管中环磷酸腺苷刺激的钠转运进行反馈抑制。
J Clin Invest. 1991 Nov;88(5):1502-10. doi: 10.1172/JCI115460.

本文引用的文献

1
Design of more potent antagonists of the antidiuretic responses to arginine-vasopressin.精氨酸加压素抗利尿反应的更强效拮抗剂的设计。
J Med Chem. 1982 Jan;25(1):45-50. doi: 10.1021/jm00343a009.
2
Water intoxication and oxytocin.水中毒与催产素。
Br Med J (Clin Res Ed). 1982 Jul 24;285(6337):243. doi: 10.1136/bmj.285.6337.243.
3
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.膜磷酸肌醇在激动剂依赖性水解后肌醇磷酸水平的变化。
Biochem J. 1983 May 15;212(2):473-82. doi: 10.1042/bj2120473.
4
Structural changes in the arginine vasopressin molecule that enhance antidiuretic activity and specificity.增强抗利尿活性和特异性的精氨酸加压素分子结构变化。
Endocrinology. 1974 Apr;94(4):1106-15. doi: 10.1210/endo-94-4-1106.
5
Synthesis and some pharmacological properties of 18 potent O-alkyltyrosine-substituted antagonists of the vasopressor responses to arginine-vasopressin.18种强效的O-烷基酪氨酸取代的精氨酸加压素血管升压反应拮抗剂的合成及某些药理特性
J Med Chem. 1985 Oct;28(10):1485-91. doi: 10.1021/jm00148a019.
6
Influence of oxytocin on renal hemodynamics and electrolyte and water excretion.催产素对肾血流动力学以及电解质和水排泄的影响。
Am J Physiol. 1986 Aug;251(2 Pt 2):F290-6. doi: 10.1152/ajprenal.1986.251.2.F290.
7
The influence of neurohypophysial hormones on renal function in the acutely hypophysectomized rat.神经垂体激素对急性垂体切除大鼠肾功能的影响。
J Physiol. 1986 Dec;381:439-52. doi: 10.1113/jphysiol.1986.sp016337.
8
Autoradiographic localization of vasopressin and oxytocin binding sites in rat kidney.大鼠肾脏中血管加压素和催产素结合位点的放射自显影定位
Kidney Int. 1988 May;33(5):959-65. doi: 10.1038/ki.1988.94.
9
A study on the release mechanism of vasopressin and oxytocin.一项关于血管加压素和催产素释放机制的研究。
Neuropeptides. 1988 Nov-Dec;12(4):199-206. doi: 10.1016/0143-4179(88)90055-8.
10
Phorbol myristate acetate, dioctanoylglycerol, and phosphatidic acid inhibit the hydroosmotic effect of vasopressin on rabbit cortical collecting tubule.佛波醇肉豆蔻酸酯乙酸盐、二辛酰甘油和磷脂酸可抑制血管升压素对兔皮质集合管的水渗透效应。
J Clin Invest. 1987 Aug;80(2):590-3. doi: 10.1172/JCI113110.

血管加压素刺激培养的大鼠髓质内集合管细胞中的磷酸肌醇水解是由催产素受体介导的。

Vasopressin-stimulated phosphoinositide hydrolysis in cultured rat inner medullary collecting duct cells is mediated by the oxytocin receptor.

作者信息

Teitelbaum I

机构信息

Department of Medicine, University of Colorado School of Medicine, Denver 80262.

出版信息

J Clin Invest. 1991 Jun;87(6):2122-6. doi: 10.1172/JCI115243.

DOI:10.1172/JCI115243
PMID:1645753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC296969/
Abstract

Studies were performed to identify the receptor that mediates AVP-stimulated phosphoinositide (PI) hydrolysis in cultured rat inner medullary collecting tubule (RIMCT) cells. While the selective V1 receptor agonist [Ho1, Phe2, Orn8] VT has no effect on inositol trisphosphate (IP3) production over the range of 10(-13)-10(-7) M, the selective V2 receptor agonist VDAVP stimulates IP3 production in dose-dependent fashion. Oxytocin stimulates IP3 production in dose-dependent fashion as well. AVP-stimulated phospholipase C activity is not inhibited by the V1 receptor antagonist d(CH2)5Tyr(Me)AVP(10(-7) M) but is eliminated by the V2 receptor antagonist d(CH2)5DTyr(Et)VAVP (10(-7) M). Similarly, the response to oxytocin is eliminated by the V2 receptor antagonist. The selective oxytocin receptor agonist [Thr4, Gly7] oxytocin does not stimulate cAMP production in RIMCT cells but does promote PI hydrolysis. The selective oxytocin receptor antagonist desGlyNH2d(CH2)5[Tyr(Me)-Thr4]OVT (10(-7) M) does not inhibit AVP-stimulated cAMP production but eliminates IP3 production in response to AVP or the V2 receptor agonist VDAVP. These studies demonstrate that AVP or a V2 receptor agonist stimulate PI hydrolysis in cultured RIMCT cells via occupancy of the oxytocin receptor.

摘要

开展了多项研究，以鉴定介导精氨酸加压素（AVP）刺激培养的大鼠髓质内层集合管（RIMCT）细胞中磷酸肌醇（PI）水解的受体。虽然选择性V1受体激动剂[Ho1，Phe2，Orn8] VT在10^(-13)-10^(-7) M范围内对肌醇三磷酸（IP3）的产生没有影响，但选择性V2受体激动剂VDAVP以剂量依赖性方式刺激IP3的产生。催产素也以剂量依赖性方式刺激IP3的产生。AVP刺激的磷脂酶C活性不受V1受体拮抗剂d(CH2)5Tyr(Me)AVP（10^(-7) M）的抑制，但被V2受体拮抗剂d(CH2)5DTyr(Et)VAVP（10^(-7) M）消除。同样，V2受体拮抗剂消除了对催产素的反应。选择性催产素受体激动剂[Thr4，Gly7]催产素不会刺激RIMCT细胞中cAMP的产生，但会促进PI水解。选择性催产素受体拮抗剂desGlyNH2d(CH2)5[Tyr(Me)-Thr4]OVT（10^(-7) M）不会抑制AVP刺激的cAMP产生，但会消除对AVP或V2受体激动剂VDAVP的IP3产生。这些研究表明，AVP或V2受体激动剂通过占据催产素受体刺激培养的RIMCT细胞中的PI水解。