Hashimoto H, Noto T, Nakajima T
Department of Neuropsychiatry, Kyoto Prefectural University of Medicine, Japan.
Neuropeptides. 1988 Nov-Dec;12(4):199-206. doi: 10.1016/0143-4179(88)90055-8.
The changes in plasma levels of arginine-vasopressin (AVP) and oxytocin (OXT) of rabbits by intraventricular administration of various drugs and their effects on the release of both hormones from the isolated posterior pituitary of rats were examined. An intraventricular injection of hypertonic saline, carbachol, angiotensin II, prostaglandin E2 or histamine to a rabbit increased the concentrations of plasma AVP and OXT, whereas serotonin decreased their plasma levels. Noradrenaline increased the concentration of OXT, but not that of AVP. Dopamine did not significantly affect the plasma level of either hormone. The release of AVP and OXT from the posterior pituitary fragments of rats was stimulated by changing the osmolality of the perfusion medium in vitro. Perfusion with medium containing dopamine suppressed the release of both hormones. However, the other bioactive amines and the drugs mentioned above did not affect the release of AVP and OXT.
研究了通过脑室内注射各种药物对家兔血浆中精氨酸加压素（AVP）和催产素（OXT）水平的影响，以及这些药物对大鼠离体垂体后叶释放这两种激素的作用。向家兔脑室内注射高渗盐水、卡巴胆碱、血管紧张素II、前列腺素E2或组胺会增加血浆AVP和OXT的浓度，而5-羟色胺则会降低它们的血浆水平。去甲肾上腺素增加了OXT的浓度，但未增加AVP的浓度。多巴胺对两种激素的血浆水平均无显著影响。通过体外改变灌注培养基的渗透压刺激大鼠垂体后叶碎片释放AVP和OXT。用含多巴胺的培养基灌注会抑制两种激素的释放。然而，上述其他生物活性胺和药物并不影响AVP和OXT的释放。
