Iyer Meera, Sato Makoto, Johnson Mai, Gambhir Sanjiv S, Wu Lily
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles 90095, USA.
Curr Gene Ther. 2005 Dec;5(6):607-18. doi: 10.2174/156652305774964695.
Gene-based therapy is a promising and flexible therapeutic approach to manage diverse types of cancer. The lack of convincing therapeutic success of current gene therapy protocols in part, can be attributed to the inability to monitor gene expression at the targeted site in the living subject. Linking molecular imaging to gene therapy will enable real-time assessment of the therapeutic process and the refinement of treatment protocols. This review will cover two common imaging modalities, positron emission tomography (PET) and bioluminescence imaging (BLI), used in pre-clinical and clinical gene therapy applications. Strategies to develop more specific and robust cancer gene therapy and imaging approaches will be discussed. Coupling PET to gene therapy of cancer has already been implemented in several clinical studies. This approach would help to improve the efficacy and safety of future gene therapy clinical trials.
基于基因的疗法是一种有前景且灵活的治疗方法，可用于治疗多种类型的癌症。目前基因治疗方案缺乏令人信服的治疗成功，部分原因可归因于无法在活体受试者的靶向部位监测基因表达。将分子成像与基因治疗相结合，将能够实时评估治疗过程并优化治疗方案。本综述将涵盖两种常见的成像方式，正电子发射断层扫描（PET）和生物发光成像（BLI），它们用于临床前和临床基因治疗应用。还将讨论开发更具特异性和稳健性的癌症基因治疗及成像方法的策略。将PET与癌症基因治疗相结合已在多项临床研究中得到应用。这种方法将有助于提高未来基因治疗临床试验的疗效和安全性。
