Whelton A
Johns Hopkins Hospital, Baltimore, Maryland 21205.
J Hypertens Suppl. 1991 Jan;9(1):S21-5.
The antihypertensive efficacies of lisinopril and captopril were compared using office sphygmomanometry and 24-h ambulatory blood pressure monitoring. In a double-blind, prospective, randomly allocated trial, the patients were given increasing doses of captopril at 25-100 mg twice a day or lisinopril at 10-40 mg once a day until a clinical response was achieved or the highest dose was reached. A response was defined as a reduction in diastolic pressure below 90 mmHg or a fall of at least 10 mmHg from baseline. The ambulatory monitoring showed that lisinopril reduced blood pressure from baseline to the final value and maintained the reduction to a greater degree than captopril throughout 24-h periods of observation. The office measurements showed a similar trend, but the intertreatment differences did not reach statistical significance. No first-dose side effects were observed with either drug. Once a day lisinopril appeared to be a more effective antihypertensive regimen than twice a day captopril.
采用诊室血压测量和24小时动态血压监测比较赖诺普利和卡托普利的降压疗效。在一项双盲、前瞻性、随机分配的试验中，患者分别接受卡托普利每日两次、剂量递增至25 - 100mg，或赖诺普利每日一次、剂量递增至10 - 40mg，直至出现临床反应或达到最大剂量。反应定义为舒张压降至90mmHg以下或较基线下降至少10mmHg。动态血压监测显示，在整个24小时观察期内，赖诺普利使血压从基线降至最终值，并比卡托普利在更大程度上维持血压下降。诊室测量显示出类似趋势，但治疗组间差异未达到统计学显著性。两种药物均未观察到首剂副作用。每日一次服用赖诺普利似乎是比每日两次服用卡托普利更有效的降压方案。
