Nagata Jun-ichi, Saito Morio
Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Tokyo, Japan.
Nutrition. 2006 Apr;22(4):395-400. doi: 10.1016/j.nut.2005.08.008. Epub 2006 Feb 2.
Indigestible dextrin (IDex) and diacylglycerol (DG) are food components with physiologic effects on lipid metabolism. Because simultaneous intake of dietary components with similar physiologic functions may produce a beneficial decrease in risk factors for lifestyle-related diseases, we investigated the physiologic effects of simultaneous IDex and DG intake.
Five-week-old male Wistar rats were fed a cholesterol-containing diet with IDex and DG (separately and combined) for 28 d.
IDex significantly decreased serum triacylglycerol concentration and increased the length of small intestinal villi, whereas DG produced significant decreases in serum high-density lipoprotein cholesterol concentration and significant increases in liver cholesterol and triacylglycerol concentrations.
IDex intake characteristically decreased serum triacylglycerol concentrations, although no additive or synergistic interaction between DG and IDex was observed. These results indicate that simultaneous intake of food components with similar physiologic functions do not necessarily produce additive or synergistic physiologic benefits.
难消化糊精（IDex）和二酰甘油（DG）是对脂质代谢具有生理作用的食物成分。由于同时摄入具有相似生理功能的膳食成分可能会有益地降低生活方式相关疾病的危险因素，因此我们研究了同时摄入IDex和DG的生理作用。
给5周龄雄性Wistar大鼠喂食含胆固醇的饮食，并分别或联合添加IDex和DG，持续28天。
IDex显著降低血清三酰甘油浓度，并增加小肠绒毛长度，而DG则显著降低血清高密度脂蛋白胆固醇浓度，并显著增加肝脏胆固醇和三酰甘油浓度。
摄入IDex可显著降低血清三酰甘油浓度，尽管未观察到DG和IDex之间存在相加或协同相互作用。这些结果表明，同时摄入具有相似生理功能的食物成分不一定会产生相加或协同的生理益处。
