Mirmiran Parvin, Ramezankhani Azra, Azizi Fereidoun
Obesity Research Center, Research Institute of Endocrine Sciences, Shaheed Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
Nutrition. 2009 May;25(5):526-31. doi: 10.1016/j.nut.2008.11.018. Epub 2009 Jan 3.
This study investigated the combined effect of saturated fat and cholesterol intake on serum lipids among Tehranian adults.
In 443 subjects >or=18 y, dietary intake was assessed. Height and weight were measured and body mass index was calculated. Serum cholesterol, triacylglycerol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol levels were calculated. Cholesterol intakes >or=300 mg/d and saturated fat intakes >or=7% of total energy were defined as high intakes. Individuals were categorized into four groups based on cholesterol and saturated fat intakes.
Subjects' mean age was 40.1 +/- 14.6 y; those in whom cholesterol and saturated fat intake was normal had significantly less energy and fat intake than those with high cholesterol and saturated fat intakes (P < 0.01). Saturated fat intake had a significant effect on serum total and HDL-C levels. Subjects with a normal saturated fat intake had significantly less serum total and HDL-C than those who had high saturated fat intake (P < 0.01 and P < 0.05, respectively). Adjusting for age, sex, and body mass index, the main effect of cholesterol intake on HDL-C was significant (P = 0.05). Mean serum HDL-C was lower in subjects who had normal cholesterol intake than in those with high cholesterol intake.
These results show that cholesterol and saturated fat intakes have no combined effect on serum low-density lipoprotein cholesterol level, whereas cholesterol intake per se affects serum HDL-C level.
本研究调查了饱和脂肪和胆固醇摄入量对德黑兰成年人血脂的综合影响。
对443名年龄≥18岁的受试者进行饮食摄入量评估。测量身高和体重并计算体重指数。计算血清胆固醇、甘油三酯、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇水平。胆固醇摄入量≥300毫克/天且饱和脂肪摄入量≥总能量的7%被定义为高摄入量。根据胆固醇和饱和脂肪摄入量将个体分为四组。
受试者的平均年龄为40.1±14.6岁;胆固醇和饱和脂肪摄入量正常的受试者的能量和脂肪摄入量明显低于胆固醇和饱和脂肪摄入量高的受试者(P<0.01)。饱和脂肪摄入量对血清总胆固醇和HDL-C水平有显著影响。饱和脂肪摄入量正常的受试者的血清总胆固醇和HDL-C明显低于饱和脂肪摄入量高的受试者(分别为P<0.01和P<0.05)。调整年龄、性别和体重指数后,胆固醇摄入量对HDL-C的主要影响显著(P=0.05)。胆固醇摄入量正常的受试者的平均血清HDL-C低于胆固醇摄入量高的受试者。
这些结果表明,胆固醇和饱和脂肪摄入量对血清低密度脂蛋白胆固醇水平没有综合影响,而胆固醇摄入量本身会影响血清HDL-C水平。