Dudarev V P, Kuz'menko V A, Fedorchenko V I
Kosm Biol Aviakosm Med. 1975 Mar-Apr;9(2):16-20.
An exposure of intact rats to a hyperoxic atmosphere of 2 atm for one hour a day during 20 days induced no changes in the gas exchange or hemoglobin and red blood cells content. The concentration of free radicals tended to decline. Thyroidectomized rats kept in a normoxic atmosphere showed anemia and gas exchange decrease. The concentration of free radicals in the tissues declined slightly. These parameters returned to the norm after the hyperoxybaric exposure. During a normoxic exposure thyroxine injections accelerated gas exchange, producing no significant changes in the red blood composition. The free-radical activity tended to increase. After a hyperoxybaric exposure similar changes took place.
让完整的大鼠每天在2个大气压的高氧环境中暴露1小时，持续20天，气体交换、血红蛋白及红细胞含量均未出现变化。自由基浓度呈下降趋势。处于常氧环境中的甲状腺切除大鼠出现贫血且气体交换减少。组织中的自由基浓度略有下降。高压氧暴露后，这些参数恢复正常。在常氧暴露期间，注射甲状腺素可加速气体交换，红细胞组成未发生显著变化。自由基活性呈上升趋势。高压氧暴露后也出现了类似变化。
