Ferreira Ronize A, Oliveira Alaide B, Ribeiro Múcio F B, Tafuri Wagner L, Vitor Ricardo W A
Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Exp Parasitol. 2006 Jun;113(2):125-9. doi: 10.1016/j.exppara.2005.12.006. Epub 2006 Feb 3.
The compound 2-hydroxy-3-(1'-propen-3-phenyl)-1,4-naphthoquinone (PHNQ6) was evaluated for activity against Toxoplasma gondii, alone or combined with sulfadiazine. Treatment with PHNQ6 combined with sulfadiazine protected at least 70 and 90% of mice infected with RH and EGS strains, respectively. Mice were treated with PHNQ6 (50 mg/kg/day) alone or combined with sulfadiazine (40 mg/L) 30 days after infection with P strain. The number of brain cysts was lower in mice treated with PHNQ6 alone or combined with sulfadiazine compared to that in control mice. Degenerated bradyzoites were observed in animals treated with PHNQ6. Infectivity of bradyzoites treated with PHNQ6 alone or combined with sulfadiazine was inhibited after in vitro incubation.
对化合物2-羟基-3-(1'-丙烯基-3-苯基)-1,4-萘醌(PHNQ6)单独或与磺胺嘧啶联合使用时抗刚地弓形虫的活性进行了评估。用PHNQ6与磺胺嘧啶联合治疗分别使感染RH和EGS株的小鼠至少70%和90%得到保护。感染P株30天后，小鼠单独用PHNQ6(50mg/kg/天)或与磺胺嘧啶(40mg/L)联合治疗。与对照小鼠相比，单独用PHNQ6或与磺胺嘧啶联合治疗的小鼠脑囊肿数量较少。在用PHNQ6治疗的动物中观察到了退化的缓殖子。单独用PHNQ6或与磺胺嘧啶联合处理的缓殖子在体外孵育后感染性受到抑制。
