Losi Elena, Bettini Ruggero, Santi Patrizia, Sonvico Fabio, Colombo Gaia, Lofthus Kristine, Colombo Paolo, Peppas Nicholas A
Pharmaceutical Department, University of Parma, Via delle Scienze 27/A, 43100 Parma, Italy.
J Control Release. 2006 Mar 10;111(1-2):212-8. doi: 10.1016/j.jconrel.2005.12.006. Epub 2006 Feb 3.
The aim of this paper was to study the applicability of the release module assemblage technology for an adaptable control of drug delivery rate and site. The elementary release module was a swellable matrix having one base convex and the other concave, named Dome Matrix. The swelling and release behavior of the release module was studied. The presence of the convex and concave bases in the swellable matrix slightly changed the overall drug delivery kinetics exhibited by a flat base cylindrical matrix having the same weight and composition. The swelling and drug release of the individual bases of the matrix was also studied to investigate the effect of the surface shape. The concave, convex and flat bases exhibited different swelling and release kinetics. The convex base released drug at faster rate than the concave base, whereas the flat base was intermediate. The release mechanisms of convex and concave bases were significantly different. The Dome Matrix module was selected for assembling several modules in a delivery system obtained by a guided insertion of the convex base into the concave base or by concave/concave base sticking. The module assemblage shows different drug release behavior depending on the geometry of assembled systems.
本文旨在研究释放模块组装技术在适应性控制药物释放速率和部位方面的适用性。基本释放模块是一种具有一个基部凸起和另一个基部凹陷的可膨胀基质，称为穹顶基质。研究了释放模块的溶胀和释放行为。可膨胀基质中凸起和凹陷基部的存在略微改变了由具有相同重量和组成的扁平基部圆柱形基质所呈现的整体药物递送动力学。还研究了基质各个基部的溶胀和药物释放，以研究表面形状的影响。凹陷、凸起和平坦基部表现出不同的溶胀和释放动力学。凸起基部比凹陷基部释放药物的速度更快，而扁平基部则介于两者之间。凸起和凹陷基部的释放机制有显著差异。选择穹顶基质模块，通过将凸起基部引导插入凹陷基部或通过凹陷/凹陷基部粘贴，在递送系统中组装多个模块。模块组装根据组装系统的几何形状表现出不同的药物释放行为。
