XPD基因Asp312Asn和Lys751Gln多态性、相应单倍型与胰腺癌风险
The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.
作者信息
Jiao Li, Hassan Manal M, Bondy Melissa L, Abbruzzese James L, Evans Douglas B, Li Donghui
机构信息
Department of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Unit 426, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
出版信息
Cancer Lett. 2007 Jan 8;245(1-2):61-8. doi: 10.1016/j.canlet.2005.12.026. Epub 2006 Feb 3.
Abstract
We evaluated the association between the XPD exon 10 Asp(312)Asn and exon 23 Lys(751)Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 patients and 386 controls frequency matched by age, gender, and race. Stratified analyses showed ever smokers carrying the Asn(312)Asn genotype had a significantly reduced risk when compared with those carrying the (312)Asp allele (OR=0.46, 95% confidence interval 0.24-0.88) (P for interaction=0.03). The (312)Asp-(751)Gln was identified as the putative at risk haplotype. Our study shows that the XPD gene polymorphism could be a genetic risk modifier for smoking-related pancreatic cancer.
摘要
我们在一项基于医院的研究中，对344例患者和386例按年龄、性别和种族进行频率匹配的对照者，评估了XPD基因第10外显子Asp(312)Asn和第23外显子Lys(751)Gln多态性与胰腺癌风险之间的关联。分层分析显示，与携带(312)Asp等位基因的吸烟者相比，携带Asn(312)Asn基因型的曾经吸烟者风险显著降低（比值比=0.46，95%置信区间0.24 - 0.88）（交互作用P值=0.03）。(312)Asp-(751)Gln被确定为假定的风险单倍型。我们的研究表明，XPD基因多态性可能是吸烟相关胰腺癌的一种遗传风险修饰因素。
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