骨髓移植中的CD4+CD25+调节性T淋巴细胞
CD4+CD25+ regulatory T lymphocytes in bone marrow transplantation.
作者信息
Joffre Olivier, van Meerwijk Joost P M
机构信息
Tolerance and Autoimmunity Section, INSERM U563, Université Paul Sabatier, IFR 30, Purpan Hospital, BP 3028, 31024 Toulouse Cedex 3, France.
出版信息
Semin Immunol. 2006 Apr;18(2):128-35. doi: 10.1016/j.smim.2006.01.005. Epub 2006 Feb 3.
Abstract
Induction of immunological tolerance to alloantigens would be the treatment of choice to prevent graft-versus-host disease (GvHD) and allograft rejection in transplantation medicine. Organisms use a variety of mechanisms to avoid potentially deadly immunity to self-antigens. The most potent self-tolerance mechanism is probably dominant tolerance assured by regulatory and suppressor T lymphocytes. It appears therefore attractive to use the same mechanism to induce transplantation-tolerance. We here review and discuss recent advances in the use of one of the best-characterized regulatory T lymphocyte populations, CD4(+)CD25(+) T cells, to prevent graft-versus-host disease and bone marrow allograft rejection.
摘要
诱导对同种异体抗原的免疫耐受将是预防移植医学中移植物抗宿主病（GvHD）和同种异体移植排斥反应的首选治疗方法。生物体利用多种机制来避免对自身抗原产生潜在致命的免疫反应。最有效的自身耐受机制可能是由调节性和抑制性T淋巴细胞确保的显性耐受。因此，利用相同机制诱导移植耐受似乎很有吸引力。我们在此回顾并讨论使用特征最明确的调节性T淋巴细胞群体之一，即CD4(+)CD25(+) T细胞，来预防移植物抗宿主病和骨髓同种异体移植排斥反应的最新进展。
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