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本文引用的文献

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Epstein-Barr virus neutralizing antibody levels and risk of multiple sclerosis.爱泼斯坦-巴尔病毒中和抗体水平与多发性硬化症风险的关系。
Mult Scler. 2012 Aug;18(8):1185-7. doi: 10.1177/1352458511433920. Epub 2012 Jan 30.
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Antigen microarrays identify CNS-produced autoantibodies in RRMS.抗原微阵列可识别 RRMS 中 CNS 产生的自身抗体。
Neurology. 2012 Feb 21;78(8):532-9. doi: 10.1212/WNL.0b013e318247f9f3. Epub 2012 Jan 18.
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Inflammatory cortical demyelination in early multiple sclerosis.早期多发性硬化症中的炎症性皮质脱髓鞘。
N Engl J Med. 2011 Dec 8;365(23):2188-97. doi: 10.1056/NEJMoa1100648.
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Probing cytokines, chemokines and matrix metalloproteinases towards better immunotherapies of multiple sclerosis.探究细胞因子、趋化因子和基质金属蛋白酶，以改善多发性硬化症的免疫治疗。
Cytokine Growth Factor Rev. 2011 Oct-Dec;22(5-6):359-65. doi: 10.1016/j.cytogfr.2011.11.005. Epub 2011 Nov 25.
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Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial.奥瑞珠单抗治疗复发缓解型多发性硬化症：一项 2 期、随机、安慰剂对照、多中心试验。
Lancet. 2011 Nov 19;378(9805):1779-87. doi: 10.1016/S0140-6736(11)61649-8. Epub 2011 Oct 31.
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Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis.脂质微阵列分析显示髓鞘衍生脂质和脂质复合物是多发性硬化症患者寡克隆带抗体的主要靶标。
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The association of intrathecal immunoglobulin synthesis and cortical lesions predicts disease activity in clinically isolated syndrome and early relapsing-remitting multiple sclerosis.鞘内免疫球蛋白合成与皮质病变的相关性可预测临床孤立综合征和早期复发缓解型多发性硬化的疾病活动度。
Mult Scler. 2012 Feb;18(2):174-80. doi: 10.1177/1352458511418550. Epub 2011 Aug 25.
8
Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis.脑膜炎症广泛存在，并与多发性硬化症的皮质病变有关。
Brain. 2011 Sep;134(Pt 9):2755-71. doi: 10.1093/brain/awr182. Epub 2011 Aug 11.
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Rituximab for secondary progressive multiple sclerosis: a case series.利妥昔单抗治疗继发进展型多发性硬化症：病例系列。
CNS Drugs. 2011 Jul;25(7):607-13. doi: 10.2165/11589390-000000000-00000.
10
Intracerebral human regulatory T cells: analysis of CD4+ CD25+ FOXP3+ T cells in brain lesions and cerebrospinal fluid of multiple sclerosis patients.脑内人类调节性 T 细胞：多发性硬化症患者脑内病变和脑脊液中 CD4+ CD25+ FOXP3+ T 细胞的分析。
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B细胞通过抗体依赖和抗体非依赖机制参与多发性硬化症的发病过程。

B cells contribute to MS pathogenesis through antibody-dependent and antibody-independent mechanisms.

作者信息

Wilson Heather L

机构信息

Vaccine and Infectious Disease Organization-International Vaccine Center, Saskatchewan, Canada.

出版信息

Biologics. 2012;6:117-23. doi: 10.2147/BTT.S24734. Epub 2012 May 7.

DOI:10.2147/BTT.S24734
PMID:22690126
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3363029/
Abstract

For many years, central dogma defined multiple sclerosis (MS) as a T cell-driven autoimmune disorder; however, over the past decade there has been a burgeoning recognition that B cells contribute to the pathogenesis of certain MS disease subtypes. B cells may contribute to MS pathogenesis through production of autoantibodies (or antibodies directed at foreign bodies, which unfortunately cross-react with self-antigens), through promotion of T cell activation via antigen presentation, or through production of cytokines. This review highlights evidence for antibody-dependent and antibody-independent B cell involvement in MS pathogenesis.

摘要

多年来，中心法则将多发性硬化症（MS）定义为一种由T细胞驱动的自身免疫性疾病；然而，在过去十年中，人们越来越认识到B细胞在某些MS疾病亚型的发病机制中发挥作用。B细胞可能通过产生自身抗体（或针对异物的抗体，不幸的是这些抗体与自身抗原有交叉反应）、通过抗原呈递促进T细胞活化或通过产生细胞因子来促成MS的发病机制。本综述重点介绍了抗体依赖性和抗体非依赖性B细胞参与MS发病机制的证据。