将分子马达与阿尔茨海默病联系起来。
Linking molecular motors to Alzheimer's disease.
作者信息
Stokin Gorazd B, Goldstein Lawrence S B
机构信息
Institute of Clinical Neurophysiology, Division of Neurology, University Medical Center, Zaloska Cesta 7, SI-1525 Ljubljana, Slovenia.
出版信息
J Physiol Paris. 2006 Mar-May;99(2-3):193-200. doi: 10.1016/j.jphysparis.2005.12.085. Epub 2006 Feb 3.
It is currently thought that Alzheimer's disease develops due to aberrant generation of amyloid-beta peptides. However, the mechanisms underlying the aberrant generation of amyloid-beta peptides remain unknown. An emerging concept suggests that impaired axonal transport may play a pivotal role in the aberrant generation of amyloid-beta peptides. Here we review and discuss advances in understanding AD with the primary focus on the possible role of molecular motors and axonal transport in its pathogenesis.
目前认为，阿尔茨海默病是由于β淀粉样肽的异常生成所致。然而，β淀粉样肽异常生成的潜在机制仍不清楚。一个新出现的概念表明，轴突运输受损可能在β淀粉样肽的异常生成中起关键作用。在此，我们回顾并讨论在理解阿尔茨海默病方面取得的进展，主要关注分子马达和轴突运输在其发病机制中的可能作用。
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