Chowdhury S, Haque F, al-Masum A, el Harith A, Karim E
Institute of Epidemiology, Disease Control & Research (IEDC&R), Mohakhali, Dhaka, Bangladesh.
Am J Trop Med Hyg. 1991 Apr;44(4):390-3. doi: 10.4269/ajtmh.1991.44.390.
In a prospective study conducted in Mymensingh district of Bangladesh, 1, 273 patients were assessed for the presence of visceral leishmaniasis (VL). Sodium antimony gluconate (SAG) was successfully administered to 715 patients with parasitologically confirmed infection. In the remaining 558, although there was clinical indication of VL, Leishmania donovani parasites could not be demonstrated. Administration of SAG in this group was on the grounds of the prevailing symptoms, exclusion of malaria and a positive direct agglutination test (DAT). Significant improvements in the clinical and hematological parameters were observed in 547 (98%) of the unconfirmed VL cases. On the basis of the parasitological findings or positive response to specific anti-Leishmania chemotherapy, the sensitivity and specificity of the DAT were 99.6% and 97.7% respectively. The results supported the reliability of DAT for diagnosis of VL at levels below that of parasitological detection.
在孟加拉国迈门辛希区进行的一项前瞻性研究中，对1273名患者进行了内脏利什曼病（VL）检查。715名经寄生虫学确诊感染的患者成功接受了葡萄糖酸锑钠（SAG）治疗。在其余558名患者中，尽管有VL的临床指征，但未发现杜氏利什曼原虫寄生虫。对该组患者使用SAG是基于主要症状、排除疟疾以及直接凝集试验（DAT）呈阳性。在547例（98%）未经证实的VL病例中，观察到临床和血液学参数有显著改善。根据寄生虫学检查结果或对特定抗利什曼原虫化疗的阳性反应，DAT的敏感性和特异性分别为99.6%和97.7%。结果支持了DAT在低于寄生虫学检测水平时对VL诊断的可靠性。
