Diaz Fernando, Rodriguez-Boulan Enrique
Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Ave, LC-300, New York, NY 10024, USA.
Dev Cell. 2006 Feb;10(2):151-2. doi: 10.1016/j.devcel.2006.01.005.
In the January 13 issue of Cell, Coyne and Bergelson describe an "Open sesame!" strategy developed by coxsackieviruses to invade the organism through the intestinal epithelium. The strategy involves coopting intrinsic signaling abilities of the apical GPI-anchored protein DAF to open the tight junction barrier, gain access to the primary receptor CAR, and activate virus internalization by a caveolin-dependent pathway.
在1月13日的《细胞》杂志上，科因和伯格elson描述了一种由柯萨奇病毒开发的“芝麻开门！”策略，该策略通过肠道上皮侵入机体。该策略包括利用顶端糖基磷脂酰肌醇锚定蛋白DAF的内在信号传导能力来打开紧密连接屏障，获得对主要受体CAR的 access，以及通过小窝蛋白依赖途径激活病毒内化。
