当然，没有这个（物质）就无法生存：SIRT6。

Certainly can't live without this: SIRT6.

作者信息

Rodgers Joseph T, Puigserver Pere

机构信息

Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

出版信息

Cell Metab. 2006 Feb;3(2):77-8. doi: 10.1016/j.cmet.2006.01.009.

DOI:10.1016/j.cmet.2006.01.009

PMID:16459306

Abstract

Cellular metabolic rates might regulate aging by impinging on genomic stability through the DNA repair pathways. A new study published in Cell (Mostoslavsky et al., 2006) reports that deficiency in one of the mammalian Sir2 homologs, SIRT6, results in genome instability through the DNA base excision repair pathway and leads to aging-associated degenerative phenotypes.

摘要

细胞代谢率可能通过DNA修复途径影响基因组稳定性来调节衰老。发表在《细胞》杂志上的一项新研究（Mostoslavsky等人，2006年）报告称，哺乳动物Sir2同源物之一SIRT6的缺陷会通过DNA碱基切除修复途径导致基因组不稳定，并引发与衰老相关的退行性表型。